CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14630
Family Name Epidermal growth factor receptor ligand AGN-PC-078X8C family
No. of Seeds 10 No. of Other Members 8
Family Centroid CFAMM00429440 Functional Category Bioactive
Superfamily Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Superfamily
Class Class 850

Cousin Family NamesSeedsMembers
Alpha-1D adrenergic receptor Ligand Terazosin Family 28 638
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Epidermal growth factor receptor and Receptor tyrosine-protein... 16 89
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
AP26113 family 16 90
SB1518 family 7 103
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Platelet-derived growth factor receptor alpha and Fibroblast g... 3 47
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Sodium channel protein type 5 subunit alpha Ligand Enecadin Fa... 1 11
Tyrosine-protein kinase Lck inhibitor 4-N-(2-chloro-6-methylph... 8 45
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 1 15
Tyrosine-protein kinase Lck inhibitor AGN-PC-073GX8 family 12 1
Epidermal growth factor receptor ligand N-[4-(3-chloro-4-fluor... 6 47
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 19 11
B2 bradykinin receptor ligand (E)-3-[6-(2-oxopyrrolidin-1-yl)p... 3 2
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Epidermal growth factor receptor ligand Pyrimido[4,5-b]indole ... 1 4
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 9 10
Insulin receptor and Insulin-like growth factor 1 receptor lig... 17 7
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 1 3
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 3 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 8 1
Epidermal growth factor receptor ligand N-[3-[7-[2-methoxy-4-(... 9 3
Epidermal growth factor receptor ligand SureCN4454332 family 18 5
Tyrosine-protein kinase Lck inhibitor AGN-PC-0762WF family 2 0
Tyrosine-protein kinase Lck inhibitor 3-[[2-(benzimidazol-1-yl... 2 0
Transient receptor potential cation channel subfamily V member... 2 4
TRAF2 and NCK-interacting protein kinase and Serine/threonine-... 2 2
TRAF2 and NCK-interacting protein kinase inhibitor 4-methoxy-3... 4 1
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 9 2
C-X-C chemokine receptor type 3 ligand 1-[3-[[(1R,5S)-3-[(5-fl... 3 2
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 4 3
Epidermal growth factor receptor ligand SureCN2989664 family 5 2
Epidermal growth factor receptor and Receptor tyrosine-protein... 8 0
Vascular endothelial growth factor receptor 2 ligand pyrimidin... 2 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 10 4
Epidermal growth factor receptor ligand Pyrido[3,4-d]pyrimidin... 3 1
Epidermal growth factor receptor ligand AGN-PC-07B1XF family 3 0
Epidermal growth factor receptor ligand 4-Anilinoquinazoline d... 2 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00429447 CHEMBL286343 Bioactive SureCN2992866
CFAMM00429440 CHEMBL473747 Bioactive AGN-PC-078X8C
CFAMM00429432 CHEMBL31588 Bioactive SureCN2987786
CFAMM00429446 CHEMBL27685 Bioactive N-[4-(3-bromo-4-fluoroanilino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]prop-2-enamide
CFAMM00429438 CHEMBL473748 Bioactive AGN-PC-078X8D
CFAMM00429444 CHEMBL516365 Bioactive AGN-PC-078X8B
CFAMM00429443 CHEMBL473944 Bioactive AGN-PC-078X8E
CFAMM00429442 CHEMBL489107 Bioactive AGN-PC-078XAK
CFAMM00429448 CHEMBL31419 Bioactive SureCN2995071
CFAMM00429441 CHEMBL32844 Bioactive N-[4-(3-bromoanilino)-7-[3-(4-methylpiperazin-1-yl)propoxy]quinazolin-6-yl]prop-2-enamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26186 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543