CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14646
Family Name Neutrophil collagenase and Stromelysin-3 inhibitor [3-[[1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-2-[(4-methoxyphenyl)methylsulfanylmethyl]-3-oxopropyl]-[2-phenyl-1-(phenylmethoxycarbonylamino)ethyl]phosphinic acid family
No. of Seeds 3 No. of Other Members 2
Family Centroid CFAMM00112895 Functional Category Bioactive
Superfamily Stromelysin-3 and Neutrophil collagenase Binder Superfamily
Class Class 647

Cousin Family NamesSeedsMembers
Gonadotropin-releasing hormone receptor Ligand decapeptide ana... 9 162
Epidermal Growth Factor family 111 209
Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... 26 1171
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
Melatonin receptor type 1A Ligand Melatonin Family 20 988
HIV-1 protease Inhibitor Atazanavir Family 16 58
Gastrin/cholecystokinin type B receptor ligand oligopeptide Ce... 35 209
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
Bacterial outer membrane Inhibitor Daptomycin Family 6 50
Somatostatin receptor type 2 ligand octapeptide Lanreotide Family 93 156
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
5-hydroxytryptamine receptor Ligand Metergolin Family 2 11
Substance-P receptor Ligand GSK424887 Family 8 184
Growth hormone receptor Ligand EP-51216 Family 34 390
CBP-501 family 7 8
Cholecystokinin receptor type A Ligand A-71378 Family 77 23
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
Lethal factor Inhibitor GM6001 Family 50 435
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Cathepsin B and Cathepsin K Inhibitor Z-arg-leu-val-agly-ile-v... 3 19
Delta-type opioid receptor and Gastrin/cholecystokinin type B ... 19 0
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Angiotensin-converting enzyme and Endothelin-converting enzyme... 2 10
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 24 64
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 46 0
C-C chemokine receptor type 5 ligand AC1LAJEM family 4 14
Pol polyprotein inhibitor pyridin-2-ylmethyl N-[(2R)-1-[[(2S,3... 15 8
Neutrophil collagenase and Stromelysin-3 inhibitor AC1MORIH fa... 7 9
Pol polyprotein inhibitor Carbamic acid, ((2-hydroxy-1,4-bis(p... 21 1
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 8 8
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 5 2
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 1 2
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 4 53
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 2 0
Growth hormone-releasing hormone receptor ligand ethyl (1S)-1'... 3 2
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-3-... 8 3
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 3 0
Somatostatin receptor type 4 ligand methyl 5-(diaminomethylide... 2 34
Prostaglandin D2 receptor 2 ligand 2-[1-[4-[(4-methoxybenzoyl)... 2 2
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 3 0
Pancreatic alpha-amylase and Gastrin/cholecystokinin type B re... 7 1
Peroxisome proliferator-activated receptor delta and Peroxisom... 1 1
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 4 3
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Substance-P receptor ligand SureCN2139814 family 7 7
Neutrophil collagenase and Interstitial collagenase inhibitor ... 1 0
Stromelysin-3 and Neutrophil collagenase inhibitor AGN-PC-074N... 3 1
Gonadotropin-releasing hormone receptor ligand methyl 4-[2-[[(... 2 1
Growth factor receptor-bound protein 2 ligand [4-[(2S)-2-aceta... 5 2
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 4 1
CGMP-dependent protein kinase inhibitor AGN-PC-0761UG family 1 2
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
Melanocortin receptor 4 and Melanocyte-stimulating hormone rec... 1 0
Angiotensin-converting enzyme and Collagenase 3 inhibitor (2S)... 2 1
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 1 0
Caspase-1 inhibitor (3S)-5-[2-(1H-indol-3-yl)acetyl]oxy-4-oxo-... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26190 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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