CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14670
Family Name Delta-type opioid receptor and Mu-type opioid receptor ligand AGN-PC-074E9U family
No. of Seeds 4 No. of Other Members 15
Family Centroid CFAMM00184012 Functional Category Bioactive
Superfamily Potassium voltage-gated channel subfamily H member 2 and Tankyrase-2 Binder Superfamily
Class Class 2895

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Mu-type opioid receptor Ligand Alvimopan Family 32 325
Zucapsacin family 7 177
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 23
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 20 35
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 3 89
Plasmepsin-2 Inhibitor PS-662477 Family 7 55
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Scytalone dehydratase Inhibitor 5-fluoro-2-hydroxy-n-isopropyl... 3 14
Histamine H3 receptor Ligand A-349821 Family 49 228
Interstitial collagenase Inhibitor N-hydroxycarbamoylmethyl-4-... 5 24
Histamine H1 receptor Ligand MDL-105212 Family 16 56
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
Caspase-3 Inhibitor 2-(4-methoxy-benzyl)isoquinoline-1,3,4-tri... 2 2
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 23 9
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 31 5
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
Urotensin-2 receptor Ligand SB-436811 Family 6 71
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 14
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
D(2) dopamine receptor Ligand Epidepride Family 31 66
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
Vasopressin V1a receptor and Vasopressin V2 receptor ligand [4... 4 7
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 2 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 3 4
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 55 36
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 8 12
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[(3... 2 11
3-hydroxyacyl-CoA dehydrogenase type-2 and Retinal dehydrogena... 1 15
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 9
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Substance-P receptor ligand AGN-PC-075NP5 family 4 8
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 10
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 4 2
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 7 9
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 6 16
Prelamin-A/C and Retinal dehydrogenase 1 inhibitor CHEMBL15810... 1 1
Pol polyprotein inhibitor CHEMBL305466 family 4 7
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 11 6
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Potassium voltage-gated channel subfamily H member 2 and Melan... 2 12
Histamine H1 receptor and Histamine H3 receptor ligand 4-[(4-m... 3 6
Substance-K receptor and Substance-P receptor ligand AGN-PC-07... 1 0
Vasopressin V1a receptor ligand 1-(4-chlorophenyl)-N-[(2R)-1-[... 2 8
Melanin-concentrating hormone receptor 1 ligand N-[1-[3-(4-chl... 1 1
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 3
Orexin receptor type 1 and Orexin receptor type 2 ligand [(2S)... 3 1
Mu-type opioid receptor ligand AGN-PC-075GAC family 16 8
B1 bradykinin receptor ligand 4-(5-chloro-4-oxochromen-3-yl)-N... 1 5
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Growth hormone secretagogue receptor type 1 ligand 2-[(2S)-1-[... 2 0
Nociceptin receptor and Kappa-type opioid receptor ligand AGN-... 1 3
Histamine H3 receptor ligand 4-[[2-[2-[(2R)-2-methylpyrrolidin... 1 1
Potassium voltage-gated channel subfamily H member 2 and Melan... 4 22
Potassium voltage-gated channel subfamily H member 2 and Melan... 5 4
Delta-type opioid receptor ligand N-[(7S)-5-(3-hydroxyphenyl)-... 9 3
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 6 2
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 15 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 3
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 7 1
Kinesin-like protein KIF11 and Potassium voltage-gated channel... 1 0
P2X purinoceptor 7 inhibitor N-(1-adamantylmethyl)-2-chloro-5-... 3 0
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 0
Melanocortin receptor 4 ligand [(3R,4S)-4-(4-chlorophenyl)-1-p... 5 8
Histamine H3 receptor and Sodium-dependent serotonin transport... 14 3
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 2 6
Melanocortin receptor 4 and Melanocortin receptor 3 ligand N-[... 1 0
Potassium voltage-gated channel subfamily H member 2 and C-C c... 2 1
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 3 1
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 7 1
Sigma non-opioid intracellular receptor 1 and D(3) dopamine re... 26 8
Pol polyprotein inhibitor 168912-67-2 family 1 0
Substance-P receptor and Substance-K receptor ligand AGN-PC-07... 1 1
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-3-(1,3-b... 4 2
Melanocortin receptor 4 and Melanocortin receptor 5 ligand 3-a... 2 2
Melanin-concentrating hormone receptor 1 ligand N-methyl-N-[(3... 2 2
Renin inhibitor (1R,5S)-N-[(2-chlorophenyl)methyl]-7-[4-[3-[(2... 9 0
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-04X9O... 2 1
C-C chemokine receptor type 5 ligand (4-chlorophenyl) N-[1-[(4... 2 2
Muscarinic acetylcholine receptor M3 ligand N-[[3-[3-[(3-methy... 5 2
Renin inhibitor N-[(2S,3S,5R)-2-amino-6-(butylamino)-3-hydroxy... 5 1
C-C chemokine receptor type 3 and Probable C-C chemokine recep... 5 2
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-07R5XZ family 2 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
D(3) dopamine receptor ligand S33084 family 1 1
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 9
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(2-chlo... 2 4
Survival motor neuron protein and Muscleblind-like protein 1 i... 1 10
Orexin receptor type 2 and Orexin receptor type 1 ligand 2-ben... 1 0
Potassium voltage-gated channel subfamily H member 2 ligand me... 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00429626 CHEMBL63232 Bioactive AGN-PC-074EJY

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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