CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14691
Family Name C-C chemokine receptor type 1 ligand SureCN8184421 family
No. of Seeds 11 No. of Other Members 10
Family Centroid CFAMM00177429 Functional Category Bioactive with Natural Product
Superfamily C-C chemokine receptor type 1 and Cannabinoid receptor 2 Binder Superfamily
Class Class 2862

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Sodium channel protein type 5 subunit alpha Ligand Flecainide ... 2 162
HIV-1 protease Inhibitor Lopinavir Family 4 25
Muscarinic acetylcholine receptor Ligand Methantheline Family 6 8
Zucapsacin family 7 177
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
C-C chemokine receptor type 5 Ligand GW873140 Family 6 78
Substance-P receptor Ligand Ezlopitant Family 10 207
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 23
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
5-hydroxytryptamine receptor 1A Ligand Robalzotan Family 9 41
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family 11 13
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Histamine H3 receptor Ligand A-349821 Family 49 228
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Angiopoietin-1 receptor and Cyclin-dependent kinase 1 Inhibito... 2 10
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Acetylcholinesterase and Cholinesterase Inhibitor Caproctamine... 7 17
Oxytocin receptor Ligand [mpa1, D-tyr(et)2, D-tic7]ot Family 43 26
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
D(2) dopamine receptor Ligand Epidepride Family 31 66
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 1 13
Histamine H3 receptor ligand 1-(4-pentan-3-ylpiperazin-1-yl)-2... 1 1
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 3 2
E3 ubiquitin-protein ligase XIAP inhibitor N-METHYLALANYL-3-ME... 3 14
Renin inhibitor N-[(2S,4S,5S,7S)-7-[2-(1-acetylpiperidin-4-yl)... 2 1
Renin inhibitor (1R,5S)-N-cyclopropyl-N-[(3-methoxy-2-methylph... 4 4
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 6 1
3-hydroxyacyl-CoA dehydrogenase type-2 and Retinal dehydrogena... 1 15
Substance-P receptor ligand AGN-PC-075NSQ family 9 3
Substance-P receptor ligand AGN-PC-075NP5 family 4 8
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 10
Carbonic anhydrase 9 and Carbonic anhydrase 14 inhibitor N-[2-... 6 10
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6S... 1 0
Orexin receptor type 1 and Orexin receptor type 2 ligand [(2S)... 3 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 28
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 6 1
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 7 1
Pol polyprotein inhibitor MDL 74538 family 11 1
Kappa-type opioid receptor and Cytochrome P450 2D6 ligand Sure... 4 3
Nociceptin receptor and Kappa-type opioid receptor ligand AGN-... 1 3
Potassium voltage-gated channel subfamily H member 2 and Melan... 5 4
Delta-type opioid receptor ligand N-[(7S)-5-(3-hydroxyphenyl)-... 9 3
Cathepsin K and Cathepsin S inhibitor (1R,2R)-N-[cyano-(2-meth... 1 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 15 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 3
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 7 1
Disintegrin and metalloproteinase domain-containing protein 17... 4 1
C-C chemokine receptor type 3 and C-C chemokine receptor type ... 3 4
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 2 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2R)-3-[4-(2-me... 18 1
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 7 1
Histamine H3 receptor ligand SureCN7244264 family 1 0
Cathepsin S and Cathepsin L1 inhibitor benzyl N-[(2S)-1-oxo-1-... 2 2
Pol polyprotein inhibitor (3S)-N-tert-butyl-2-[(2R)-2-[(3S,6S,... 3 1
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-3-(1,3-b... 4 2
Scytalone dehydratase inhibitor 2-cyano-N-[(1S,2R)-1-(2-cyanop... 5 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
Histamine H3 receptor and D(3) dopamine receptor ligand AGN-PC... 1 0
C-C chemokine receptor type 5 ligand (4-chlorophenyl) N-[1-[(4... 2 2
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2C9 inhib... 2 1
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 3 1
Neuropeptide Y receptor type 1 and Sodium-dependent serotonin ... 2 7
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
D(3) dopamine receptor ligand S33084 family 1 1
C-C chemokine receptor type 2 ligand (E)-N-[(1S,3R)-3-[[4-(4-m... 1 6
NP 2-(7-methoxy-4,8-dimethyl-2-oxo-2h-chromen-3-yl)-n-(3-(2-ox... 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00429728 CHEMBL418589 Bioactive SureCN8189885
CFAMM00429719 CHEMBL33223 Bioactive SureCN8190015
CFAMM00429725 CHEMBL33340 Bioactive SureCN8186642
CFAMM00429717 CHEMBL289902 Bioactive 2,7-dibromo-N-[1-[[(1E)-cycloocten-1-yl]methyl]-1-ethylpiperidin-1-ium-4-yl]-9H-xanthene-9-carboxamide;iodide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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