CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14719
Family Name Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha and Protein farnesyltransferase subunit beta inhibitor 1n9a family
No. of Seeds 4 No. of Other Members 1
Family Centroid CFAMM00429891 Functional Category Bioactive
Superfamily Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha and Protein farnesyltransferase subunit beta Binder Superfamily
Class Class 177

Cousin Family NamesSeedsMembers
Cytochrome P450 3A4 Inhibitor Clotrimazole Family 16 145
Prothrombin Inhibitor Dabigatran Family 7 182
Vascular endothelial growth factor Inhibitor PTC299 Family 6 145
Farnesyltransferase beta subunit, putative Inhibitor Zarnestra... 10 56
Translocator protein Inhibitor Emapunil Family 7 89
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
Vascular endothelial growth factor receptor 2 Ligand XL999 Family 11 87
Histamine H3 receptor Ligand SCH79687 Family 11 29
Farnesyltransferase beta subunit, putative and Protein farnesy... 20 81
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-cyanobenzyl... 14 13
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-aminobenzyl... 3 6
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 45
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-cyanobenzyl... 2 1
Farnesyltransferase beta subunit, putative and Protein farnesy... 12 4
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 4
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 11 22
Macrophage colony-stimulating factor 1 receptor ligand SureCN1... 28 9
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 2
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
Adenosine receptor A2a ligand AGN-PC-01LVXW family 2 25
Peroxisome proliferator-activated receptor gamma ligand 1-[(4-... 7 29
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 9 3
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 3 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 7 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 13 1
Protein farnesyltransferase alpha subunit and Protein farnesyl... 5 0
Melanocortin receptor 4 ligand AGN-PC-076AMO family 17 8
5-hydroxytryptamine receptor 2B ligand SureCN1299437 family 6 7
Orexin receptor type 2 and Orexin receptor type 1 ligand (2R)-... 12 16
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Dipeptidyl peptidase 4 inhibitor 7-(aminomethyl)-6-(2-chloroph... 2 5
Macrophage colony-stimulating factor 1 receptor and Receptor-t... 2 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 3
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 1
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00429891 CHEMBL30059 Bioactive 1n9a
CFAMM00429890 CHEMBL29980 Bioactive histidine derivative, 37
CFAMM00429892 CHEMBL282166 Bioactive SureCN7050838

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26851 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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