CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14722
Family Name Corticotropin-releasing factor receptor 1 and Corticotropin-releasing factor receptor 2 ligand AGN-PC-076HU2 family
No. of Seeds 1 No. of Other Members 0
Family Centroid CFAMM00429898 Functional Category Bioactive
Superfamily D(2) dopamine receptor and Interleukin-1 receptor type 1 Binder Superfamily
Class Class 914

Cousin Family NamesSeedsMembers
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Histamine H1 receptor Ligand Mizolastine Family 14 603
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Vascular endothelial growth factor Inhibitor PTC299 Family 6 145
Translocator protein Inhibitor Emapunil Family 7 89
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
HCV NS4B protein Inhibitor Clemizole Family 2 43
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
Corticotropin-releasing factor receptor 1 Ligand CP-154526 Family 9 29
Corticotropin-releasing factor receptor 1 Ligand CRA1000 Family 4 39
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Prostaglandin G/H synthase 2 Inhibitor RWJ-67657 Family 3 33
Interleukin-1 receptor type 1 and Mitogen-activated protein ki... 7 151
Steroid 17-alpha-hydroxylase/17,20 lyase Inhibitor 1-(1-(4-thi... 3 36
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-cyanobenzyl... 14 13
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
Aromatase and Thromboxane-A synthase Inhibitor 6-(1h-imidazol-... 3 8
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 1 9
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-(4-e... 2 5
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42
Hepatocyte growth factor receptor Ligand 3-(phenylsulfonyl)-1h... 17 59
Prostaglandin G/H synthase 2 Inhibitor GW-637185X Family 27 48
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-bromobenzyl... 3 0
Type-2 angiotensin II receptor Ligand L-158282 Family 24 58
Type-2 angiotensin II receptor Ligand L-158809 Family 22 136
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 4 22
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-(2-(4-... 25 10
Potassium voltage-gated channel subfamily H member 2 and Neuro... 2 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 6 60
Platelet-activating factor receptor ligand AGN-PC-0750SP family 4 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 7 4
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 1 2
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 27
D(4) dopamine receptor and D(2) dopamine receptor ligand 4-met... 13 8
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 10
Nuclear receptor ROR-gamma and Mitogen-activated protein kinas... 1 10
Growth hormone secretagogue receptor type 1 and Dihydrofolate ... 3 6
Substance-K receptor and Cytochrome P450 2D6 ligand 158848-32-... 4 4
Corticotropin-releasing factor receptor 1 ligand 9-(2-bromo-4-... 15 3
Fatty-acid amide hydrolase 1 inhibitor 5-[5-(4-chlorophenyl)su... 2 4
Fatty-acid amide hydrolase 1 inhibitor [5-(4-chlorophenyl)tria... 2 2
Somatostatin receptor type 5 and Somatostatin receptor type 2 ... 6 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Aurora kinase B and Vascular endothelial growth factor recepto... 1 2
TGF-beta receptor type-1 and TGF-beta receptor type-2 ligand S... 2 2
Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... 4 5
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 1
Neuropeptide Y receptor type 5 and Cytochrome P450 1A2 ligand ... 8 19
Neuropeptide Y receptor type 5 ligand 2-(3-phenylpiperidin-1-y... 6 2
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 3 4
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 5 2
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor AG... 3 1
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
Cannabinoid receptor 2 ligand 4-[[2-tert-butyl-1-(cyclohexylme... 2 0
Prostaglandin G/H synthase 2 inhibitor 4-N,4-N-diethyl-2-(4-me... 5 1
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 1 0
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 4 1
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 2 3
Nociceptin receptor and Mu-type opioid receptor ligand 2-(3-ch... 2 0
Focal adhesion kinase 1 and Protein-tyrosine kinase 2-beta inh... 1 1
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 2 4
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 5
Integrin beta-2 and Intercellular adhesion molecule 1 inhibito... 2 9
Integrin beta-2 and Intercellular adhesion molecule 1 inhibito... 1 3
Integrin beta-2 and Intercellular adhesion molecule 1 inhibito... 3 3
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00429898 CHEMBL282289 Bioactive AGN-PC-076HU2

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

48711 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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