CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14723
Family Name Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2-methoxyphenyl)phenyl]-2-[[(4S)-3-methylsulfonyl-1,3-thiazolidine-4-carbonyl]amino]propanoic acid family
No. of Seeds 4 No. of Other Members 0
Family Centroid CFAMM00429899 Functional Category Bioactive
Superfamily Integrin beta-1 and Integrin alpha-4 Binder Superfamily 8
Class Class 590

Cousin Family NamesSeedsMembers
Thyroid hormone receptor alpha ligand thyroid hormone analog L... 10 61
Oxytocin receptor Ligand Oxytocin Family 30 182
Beta-1 adrenergic receptor Ligand Esmolol Family 5 39
Penicillin binding protein Inhibitor Cefadroxil Family 5 17
Glucan synthesis regulatory protein Inhibitor Caspofungin Family 17 71
Glycoprotein IIb/IIIa receptor Ligand Tirofiban Family 4 173
HIV-1 protease Inhibitor Lopinavir Family 4 25
Thymopentin family 20 133
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Endothelin-1 receptor Ligand Atrasentan Family 127 336
C-C chemokine receptor type 5 Ligand GW873140 Family 6 78
Integrin alpha-4 Inhibitor Firategrast Family 3 93
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 6 33
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Vasopeptidase Inhibitor Fasidotril Family 3 7
Plasmepsin-2 Inhibitor KNI-727 Family 3 37
Vasopeptidase Inhibitor Sampatrilat Family 25 9
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Cruzipain Inhibitor WRR-204 Family 18 35
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family 11 13
Plasmepsin-2 Inhibitor PS-662477 Family 7 55
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Cathepsin B and Cathepsin K Inhibitor Z-ala-leu-tyr(me)-agly-i... 2 1
Cathepsin B and Cathepsin L1 Inhibitor MDL-2170 Family 17 24
Histamine H3 receptor Ligand A-349821 Family 49 228
Angiopoietin-1 receptor and Cyclin-dependent kinase 1 Inhibito... 2 10
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-il... 36 12
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Plasmepsin-2 Inhibitor KNI-10079 Family 19 8
Oxytocin receptor Ligand [mpa1, D-tyr(et)2, D-tic7]ot Family 43 26
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 49 19
Mu-type opioid receptor Ligand H-tyr-d-ala-aic-asp-val-val-gly... 48 8
Genome polyprotein Inhibitor Acasp-glu-cha-val-prb-cys Family 13 18
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Sodium-dependent dopamine transporter Inhibitor Bip-tyr-thr-pr... 8 2
Pol polyprotein inhibitor 180968-31-4 family 8 13
Endothelin-1 receptor and Endothelin B receptor ligand (2R,3R,... 5 4
Neprilysin and Angiotensin-converting enzyme inhibitor AGN-PC-... 3 7
Glutamate receptor ionotropic, kainate 2 ligand (2S,3S,4S)-4-[... 4 10
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 6 1
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 6 1
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 2 13
Neprilysin inhibitor SureCN389939 family 5 6
Caspase-3 and Caspase-7 inhibitor SureCN14113084 family 2 6
Caspase-3 and Caspase-7 inhibitor valine aspartyl ketone 31 fa... 1 8
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[4-(ben... 12 20
Dipeptidyl peptidase 4 and Seprase inhibitor (2R)-2-[4-[[[(2S)... 17 19
Integrin beta-1 and Integrin alpha-4 inhibitor AGN-PC-074GDW f... 9 2
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-ethy... 7 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(3-benz... 7 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[1-(ben... 6 5
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(4S)-3... 3 24
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN6453971 f... 3 4
Pol polyprotein inhibitor AC1LADQG family 7 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2,6-... 16 23
Caspase-3 and Caspase-7 inhibitor (3S)-5-benzylsulfanyl-3-[[(2... 1 2
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 6 3
Pol polyprotein inhibitor MDL 74538 family 11 1
Kappa-type opioid receptor and Cytochrome P450 2D6 ligand Sure... 4 0
Angiotensin-converting enzyme and Neprilysin inhibitor (2S,5R)... 15 3
Kinesin-like protein KIF11 inhibitor 2-amino-5-(4-methoxypheny... 1 4
Integrin beta-3 and Integrin alpha-IIb inhibitor (2S)-5-(diami... 2 0
Angiotensin-converting enzyme 2 and Neprilysin inhibitor (2S)-... 6 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2,6-... 2 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2R)-3-[4-(2-me... 18 1
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN5686827 f... 7 3
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-2... 2 21
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 3 1
Pol polyprotein inhibitor N-[2-Hydroxy-2-(8-Isopropyl-6,9-Diox... 7 6
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN6429531 f... 2 0
72 kDa type IV collagenase and Collagenase 3 inhibitor SureCN7... 5 2
Neprilysin inhibitor benzyl (2S)-3-(4-hydroxyphenyl)-2-[[2-(su... 1 1
Cathepsin S and Cathepsin L1 inhibitor benzyl N-[(2S)-1-oxo-1-... 2 2
Neutrophil collagenase and Collagenase 3 inhibitor [4-(4-chlor... 2 0
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 0
Neprilysin inhibitor (2S)-4-methoxy-2-[[1-[[(1R,2S)-2-(4-metho... 1 0
Renin inhibitor ethyl N-[1-[[1-[[(2S,3R,4S)-1-cyclohexyl-3,4-d... 2 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 9
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[2-(die... 2 1
Angiotensin-converting enzyme inhibitor (2S,4S)-1-[(2S)-2-meth... 1 0
Dipeptidyl peptidase 4 inhibitor 3-[[2-[(2S,4S)-2-cyano-4-fluo... 5 1
Glutamate receptor ionotropic, kainate 1 and Glutamate recepto... 1 2
Beta-lactamase and Histone-lysine N-methyltransferase 2A inhib... 1 7
(2S)-2-[(2-methoxyphenyl)methylcarbamoylamino]-4-methylsulfany... 3 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00429900 CHEMBL444036 Bioactive (2S)-3-[4-(2-methoxyphenyl)phenyl]-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoic acid
CFAMM00429899 CHEMBL29703 Bioactive (2S)-3-[4-(2-methoxyphenyl)phenyl]-2-[[(4S)-3-methylsulfonyl-1,3-thiazolidine-4-carbonyl]amino]propanoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27038 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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