CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14729
Family Name Prothrombin inhibitor AGN-PC-073GVF family
No. of Seeds 12 No. of Other Members 1
Family Centroid CFAMM00429965 Functional Category Bioactive
Superfamily Prothrombin and Trypsin-1 Binder Superfamily
Class Class 1006

Cousin Family NamesSeedsMembers
Transient receptor potential cation channel subfamily V member... 16 295
Transient receptor potential cation channel subfamily V member... 6 66
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Aurora kinase B and Aurora kinase A Inhibitor PF-03814735 Family 2 12
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Alpha-1A adrenergic receptor Ligand L-771688 Family 8 14
D(2) dopamine receptor and D(3) dopamine receptor Ligand A-706... 4 20
Transient receptor potential cation channel subfamily V member... 2 26
Prothrombin inhibitor SureCN5855286 family 15 8
Prothrombin inhibitor SureCN7371121 family 13 3
Prothrombin inhibitor SureCN5854779 family 4 9
Prothrombin inhibitor 2-[6-chloro-3-[(2,2-difluoro-2-pyridin-2... 5 0
Prothrombin inhibitor SureCN5856722 family 3 16
Corticotropin-releasing factor receptor 1 ligand 5-chloro-1-[(... 1 2
Neutrophil elastase inhibitor 2-[2-oxo-6-phenyl-3-(2-pyridin-2... 1 2
Neutrophil elastase inhibitor SureCN7284457 family 4 6
Prothrombin inhibitor (2S)-N-[(6-carbamimidoylpyridin-3-yl)met... 2 14
Cathepsin K and Potassium voltage-gated channel subfamily H me... 5 1
Mitogen-activated protein kinase 1 and Cytochrome P450 3A4 inh... 1 0
Prothrombin and Trypsin-1 inhibitor SureCN12636557 family 9 1
Prothrombin and Trypsin-1 inhibitor 2-[6-methyl-2-oxo-3-(2-pyr... 4 2
Prothrombin inhibitor AGN-PC-09QKE4 family 1 0
Neuropeptide Y receptor type 5 ligand (5E)-5-[(4S,5S)-4-(4-flu... 18 3
Toll-like receptor 7 ligand 4-amino-1-[[6-[(2S)-2-(pyrrolidin-... 4 0
Beta-secretase 1 and Beta-secretase 2 inhibitor 5-[(1R)-3-amin... 8 1
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 6 8
Neutrophil elastase inhibitor N-[(2S)-3-methyl-1-oxo-1-[(2S)-2... 4 4
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2C9 inhib... 3 0
Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... 2 0
C-X-C chemokine receptor type 3 ligand 1-[3-[[(1R,5S)-3-[[7-(t... 3 1
CGMP-dependent protein kinase inhibitor 1-[4-acetyl-3-[[4-[5-(... 2 0
Prothrombin inhibitor 2-[4-methyl-5-[[[2-[6-methyl-2-oxo-3-(2-... 1 0
Platelet-activating factor receptor ligand SureCN9853140 family 3 3
Neuropeptide Y receptor type 5 ligand SureCN4464548 family 17 2
Beta-secretase 1 and Beta-secretase 2 inhibitor SureCN4964150 ... 3 0
Transient receptor potential cation channel subfamily V member... 3 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 4 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN8... 3 0
D(4) dopamine receptor ligand SureCN4006627 family 1 0
Glycogen synthase kinase-3 beta inhibitor SureCN13987027 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00429953 CHEMBL418017 Bioactive AGN-PC-020Q4X
CFAMM00429959 CHEMBL29744 Bioactive AGN-PC-073GYJ
CFAMM00429965 CHEMBL29389 Bioactive AGN-PC-073GVF
CFAMM00429958 CHEMBL29592 Bioactive SureCN7715240
CFAMM00429964 CHEMBL28966 Bioactive AGN-PC-073GYN
CFAMM00429957 CHEMBL284225 Bioactive 2-[6-chloro-3-[[2,2-difluoro-2-(1-oxidopyridin-1-ium-2-yl)ethyl]amino]-2-oxopyrazin-1-yl]-N-[[2-(trifluoromethyl)phenyl]methyl]acetamide
CFAMM00429963 CHEMBL287417 Bioactive SureCN7371718
CFAMM00429956 CHEMBL285796 Bioactive AGN-PC-00KAJQ
CFAMM00429962 CHEMBL285579 Bioactive AGN-PC-073GZ5
CFAMM00429955 CHEMBL282837 Bioactive 2-(6-CHLORO-3-{[2,2-DIFLUORO-2-(1-OXIDO-2-PYRIDINYL)ETHYL]AMINO}-2-OXO-1(2H)-PYRAZINYL)-N-[(2-FLUOROPHENYL)METHYL]ACETAMIDE
CFAMM00429961 CHEMBL29510 Bioactive 2-[6-chloro-3-[[2,2-difluoro-2-(1-oxidopyridin-1-ium-2-yl)ethyl]amino]-2-oxopyrazin-1-yl]-N-[(2,5-difluorophenyl)methyl]acetamide
CFAMM00429960 CHEMBL284871 Bioactive AGN-PC-073GY3

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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