CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1473
Family Name Sigma non-opioid intracellular receptor 1 ligand (1R)-1'-benzylspiro[1H-2-benzofuran-3,4'-piperidine]-1-ol family
No. of Seeds 7 No. of Other Members 27
Family Centroid CFAMM00323990 Functional Category Bioactive
Superfamily Sodium-dependent dopamine transporter and Sodium-dependent serotonin transporter Binder Superfamily 3
Class Class 100

Cousin Family NamesSeedsMembers
Opioid receptor ligand synthetic opioid methadone analog Dextr... 2 108
Alpha-1B adrenergic receptor ligand Morpholine derivative Phen... 4 152
Dopamine reuptake and Noradrenergic re-uptake Inhibitor Cocain... 13 136
Muscarinic acetylcholine receptor M1 Ligand Trihexyphenidyl Fa... 14 199
Histamine H1 receptor ligand diphenylpiperidine analog Dipheny... 13 224
Histamine H1 receptor Ligand Chlophedianol Family 4 46
Nicotinic acetylcholine receptor Ligand Benztropine Mesylate F... 10 20
Muscarinic acetylcholine receptor Ligand Umeclidinium Family 7 50
Peptide deformylase, mitochondrial Inhibitor Hydroxamates Family 6 17
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Sulfen... 5 13
Substance-P receptor Ligand L-733060 Family 19 71
Adenosine receptor A3 and Mu-type opioid receptor Ligand GBR-1... 80 110
Cytochrome P450 2D6 Inhibitor Bs 7840 Family 4 9
Potassium voltage-gated channel subfamily A member 5 Ligand 2-... 3 1
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 7 19
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 11 3
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 9 7
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 2 11
Sigma non-opioid intracellular receptor 1 ligand 2-[(3R)-1'-(c... 2 0
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-076TWX... 8 5
Sigma non-opioid intracellular receptor 1 ligand SureCN5315520... 3 11
Sigma non-opioid intracellular receptor 1 ligand 1-methoxy-1'-... 1 1
Sodium-dependent dopamine transporter and Transporter inhibito... 2 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 3 0
Sigma non-opioid intracellular receptor 1 ligand SureCN7425449... 2 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 0
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-0793IB... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00323996 CHEMBL137990 Bioactive 1'-benzylspiro[3,4-dihydroisochromene-1,4'-piperidine]-3-ol
CFAMM00324007 CHEMBL358579 Bioactive (1'-benzylspiro[1H-2-benzofuran-3,4'-piperidine]-1-yl)methanol
CFAMM00324006 CHEMBL466096 Bioactive AGN-PC-0793KJ
CFAMM00324018 CHEMBL1645206 Bioactive AGN-PC-09QMK8
CFAMM00323991 CHEMBL1171689 Bioactive (1S)-1'-(2-phenylethyl)spiro[1H-2-benzofuran-3,4'-piperidine]-1-ol
CFAMM00323990 CHEMBL1171727 Bioactive (1R)-1'-benzylspiro[1H-2-benzofuran-3,4'-piperidine]-1-ol
CFAMM00324016 CHEMBL138533 Bioactive AGN-PC-00GVMJ

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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