CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14742
Family Name Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-(3-fluorophenyl)-3-[[2-[6-methyl-2-oxo-3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-ylmethylamino)pyrazin-1-yl]acetyl]amino]propanoic acid family
No. of Seeds 10 No. of Other Members 0
Family Centroid CFAMM00430027 Functional Category Bioactive
Superfamily Integrin beta-3 and Integrin alpha-V Binder Superfamily 12
Class Class 639

Cousin Family NamesSeedsMembers
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Integrin beta-3 Inhibitor Elarofiban Family 28 45
Integrin alpha-V and Integrin beta-3 Inhibitor SB-223245 Family 27 36
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
D(2) dopamine receptor and D(3) dopamine receptor Ligand A-706... 4 20
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 6-(4-... 3 6
Integrin beta-3 and Integrin alpha-V inhibitor AGN-PC-03RR5Q f... 3 2
Integrin beta-3 and Integrin alpha-V inhibitor methyl (3S)-3-(... 12 13
Integrin beta-3 and Integrin alpha-V inhibitor SureCN547914 fa... 8 32
Integrin alpha-V and Integrin beta-5 inhibitor SureCN6563167 f... 2 10
Integrin beta-3 and Integrin alpha-V inhibitor SureCN3888804 f... 11 13
Integrin beta-3 and Integrin alpha-V inhibitor (3R)-3-quinolin... 6 8
Prothrombin and Cationic trypsin inhibitor tert-butyl N-[(2R)-... 4 3
Integrin beta-3 and Integrin alpha-V inhibitor (2S)-3-[[4-[2-(... 3 3
5-hydroxytryptamine receptor 1A ligand AGN-PC-03ZB72 family 10 8
Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-[[2-[6-m... 13 12
Carboxypeptidase B2 and Carboxypeptidase B inhibitor 3-(6-amin... 5 10
Integrin beta-3 and Integrin alpha-V inhibitor SureCN6359092 f... 9 5
Tyrosine-protein kinase ITK/TSK and Receptor-type tyrosine-pro... 1 0
Renin inhibitor (3R)-4-[[(2S,5S)-1-cyclohexyl-3-hydroxy-6-meth... 3 4
Corticotropin-releasing factor receptor 1 ligand Pyridopyrazin... 3 5
Integrin beta-3 and Integrin alpha-V inhibitor (2S)-2-[[(1R,4S... 3 0
B1 bradykinin receptor ligand AGN-PC-005XAO family 3 17
Integrin beta-3 and Integrin alpha-V inhibitor (2S)-2-(benzene... 3 2
Integrin beta-3 and Integrin alpha-V inhibitor (2S)-3-[5-methy... 4 5
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 18 5
Integrin beta-3 and Integrin alpha-V inhibitor SureCN2833591 f... 4 6
Integrin beta-1 and Integrin alpha-5 inhibitor (2S)-2-[(2,6-di... 6 5
Integrin beta-3 and Integrin alpha-V inhibitor SureCN2842307 f... 4 0
B1 bradykinin receptor ligand methyl 2-fluoro-6-[3-fluoro-4-[[... 22 11
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 6-(di... 4 8
Integrin beta-3 and Integrin alpha-V inhibitor AGN-PC-00IW9E f... 3 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor 6-... 1 0
G-protein coupled bile acid receptor 1 ligand 2-(ethylamino)-6... 5 4
Integrin alpha-V and Integrin beta-6 inhibitor 3-[[2-[4-[(4-me... 4 3
Integrin beta-3 and Integrin alpha-IIb inhibitor (3S)-3-[[3-(2... 4 2
Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-[[2-[4-(... 3 0
Integrin beta-3 and Integrin alpha-IIb inhibitor (3S)-3-[[2-[(... 3 1
Integrin beta-1 and Integrin alpha-5 inhibitor 2-[(2,6-dimethy... 9 1
Cannabinoid receptor 2 ligand AGN-PC-00SRU5 family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00430030 CHEMBL415956 Bioactive (3S)-3-[[2-[6-cyclopropyl-2-oxo-3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-ylmethylamino)pyridin-1-yl]acetyl]amino]-3-(3-fluorophenyl)propanoic acid
CFAMM00430036 CHEMBL301301 Bioactive (3S)-3-[[2-[3-chloro-2-methyl-6-oxo-5-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-ylmethylamino)pyrazin-1-yl]acetyl]amino]-3-(3-fluorophenyl)propanoic acid
CFAMM00430029 CHEMBL283795 Bioactive (3S)-3-(3-fluorophenyl)-3-[[2-[(3S)-2-oxo-3-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]pyrrolidin-1-yl]acetyl]amino]propanoic acid
CFAMM00430035 CHEMBL299110 Bioactive (3S)-3-[[2-[3-chloro-2-cyclopropyl-6-oxo-5-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-ylmethylamino)pyrazin-1-yl]acetyl]amino]-3-(3-fluorophenyl)propanoic acid
CFAMM00430028 CHEMBL432980 Bioactive (3S)-3-(3-fluoro-4-phenylphenyl)-3-[[2-[(3S)-2-oxo-3-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]pyrrolidin-1-yl]acetyl]amino]propanoic acid
CFAMM00430034 CHEMBL53145 Bioactive (3S)-3-[[2-[3-chloro-2-ethyl-6-oxo-5-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-ylmethylamino)pyrazin-1-yl]acetyl]amino]-3-(3-fluorophenyl)propanoic acid
CFAMM00430027 CHEMBL53503 Bioactive (3S)-3-(3-fluorophenyl)-3-[[2-[6-methyl-2-oxo-3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-ylmethylamino)pyrazin-1-yl]acetyl]amino]propanoic acid
CFAMM00430033 CHEMBL53122 Bioactive (3S)-3-[[2-[6-cyclopropyl-2-oxo-3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-ylmethylamino)pyrazin-1-yl]acetyl]amino]-3-(3-fluorophenyl)propanoic acid
CFAMM00430032 CHEMBL54259 Bioactive (3S)-3-[[2-[6-ethyl-2-oxo-3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-ylmethylamino)pyrazin-1-yl]acetyl]amino]-3-(3-fluorophenyl)propanoic acid
CFAMM00430031 CHEMBL323831 Bioactive (3S)-3-[[2-[(3S)-2-oxo-3-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]pyrrolidin-1-yl]acetyl]amino]-3-phenylpropanoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

46004 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543