CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14756
Family Name Growth hormone secretagogue receptor type 1 ligand 2-amino-2-methyl-N-[(2R)-1-oxo-5-phenyl-1-[4-[2-(propan-2-ylsulfonylamino)phenyl]piperazin-1-yl]pentan-2-yl]propanamide family
No. of Seeds 4 No. of Other Members 2
Family Centroid CFAMM00430115 Functional Category Bioactive with Natural Product
Superfamily Oxytocin receptor and Vasopressin V1a receptor Ligand L-368899 Superfamily
Class Class 1656

Cousin Family NamesSeedsMembers
Sodium channel Ligand xylidine derivative Mepivacaine Family 10 114
Alpha adrenergic receptor Ligand Droperidol Family 20 244
Sodium channel protein type 5 subunit alpha Ligand Procainamid... 7 291
Angiotensin-converting enzyme Inhibitor Benazepril Family 7 123
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 43 161
Motilin receptor Ligand GSK962040 Family 30 457
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
Pan-DAC Inhibitor AR-42 Family 21 153
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Integrin alpha-4 Inhibitor BIO-1211 Family 16 83
Vasopressin V2 receptor Ligand FR161282 Family 17 83
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
Potassium voltage-gated channel subfamily A member 5 Ligand N-... 8 32
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Integrin beta-3 Inhibitor L-750034 Family 7 38
Aromatase Inhibitor 3-(4-amino-phenyl)-1-methyl-pyrrolidine-2,... 4 8
Acetyl-CoA acetyltransferase, mitochondrial Inhibitor Octanoic... 4 14
Cholecystokinin receptor type A Ligand VL-1499 Family 12 133
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 3 26
Beta-secretase 1 and Cathepsin D Inhibitor GRL-7234 Family 17 148
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Leukotriene A-4 hydrolase Inhibitor N5-[4-benzylphenyl]-l-glut... 2 1
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 1 1
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Mitogen-activated protein kinase 14 Inhibitor Dihydro-quinolin... 3 14
Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96
Leukotriene A-4 hydrolase Inhibitor SA-6541 Family 4 32
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
Prothrombin and Plasminogen inhibitor [(1R)-5-amino-1-[[2-[N-(... 1 0
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 10
72 kDa type IV collagenase and Stromelysin-1 inhibitor [(2S)-2... 9 6
Cathepsin K and Cathepsin B inhibitor AGN-PC-01Z23J family 2 0
Melanocortin receptor 4 and Melanocortin receptor 5 ligand N-[... 16 117
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 11 8
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 6 6
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 6 5
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 2 7
Substance-P receptor ligand (2S,4S)-2-N-[3-(diethylamino)propy... 2 7
Matrix metalloproteinase-9 and Stromelysin-1 inhibitor N-[(2S)... 1 1
Dipeptidyl peptidase 4 inhibitor SureCN1499864 family 4 7
Melanocortin receptor 4 and Melanocortin receptor 5 ligand AC1... 5 37
Melanocortin receptor 4 ligand (3R)-N-[(2R)-3-(4-chlorophenyl)... 6 9
D(4) dopamine receptor ligand 1-Piperidineacetamide, 4-(2-cyan... 3 7
Baculoviral IAP repeat-containing protein 2 and E3 ubiquitin-p... 2 1
Oxytocin receptor ligand (2R)-2-[(2R,5R)-5-(2,3-dihydro-1H-ind... 2 0
Substance-P receptor and Potassium voltage-gated channel subfa... 5 0
Melanocortin receptor 4 and Melanocortin receptor 5 ligand (3R... 6 1
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-1-... 3 3
Nociceptin receptor and Mu-type opioid receptor ligand N,N-dim... 5 4
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 11 9
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 3 0
Angiotensin-converting enzyme inhibitor (2S)-2-[[(3R)-5-(carbo... 6 4
Suppressor of tumorigenicity 14 protein and Plasminogen inhibi... 10 15
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(cyanomethyl)-... 1 6
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 14 5
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 2
Melanocortin receptor 4 and Cytochrome P450 3A4 ligand 2-amino... 52 12
Melanocortin receptor 4 ligand N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-c... 26 13
Sodium channel protein type 9 subunit alpha ligand tert-butyl ... 2 30
5-hydroxytryptamine receptor 7 ligand 3-ethyl-3-[4-[4-(4-fluor... 3 1
Melanocortin receptor 4 ligand SureCN4532266 family 8 0
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 7 12
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 11 4
72 kDa type IV collagenase and Disintegrin and metalloproteina... 1 5
Suppressor of tumorigenicity 14 protein and Prothrombin inhibi... 2 5
Neprilysin and Angiotensin-converting enzyme inhibitor 3-[(3S)... 1 0
Collagenase 3 and Interstitial collagenase inhibitor (2R,3S)-N... 1 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 3 3
Kappa-type opioid receptor and Delta-type opioid receptor liga... 3 1
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide de... 2 4
C5a anaphylatoxin chemotactic receptor 1 ligand SureCN12047568... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00430119 CHEMBL33182 Bioactive 2-[[2-[4-[(2R)-2-[(2-amino-2-methylpropanoyl)amino]-5-phenylpentanoyl]piperazin-1-yl]phenyl]sulfamoyl]acetic acid
CFAMM00430117 CHEMBL284295 Bioactive methyl 2-[[2-[4-[(2R)-2-[(2-amino-2-methylpropanoyl)amino]-5-phenylpentanoyl]piperazin-1-yl]phenyl]sulfamoyl]acetate
CFAMM00430115 CHEMBL432461 Bioactive 2-amino-2-methyl-N-[(2R)-1-oxo-5-phenyl-1-[4-[2-(propan-2-ylsulfonylamino)phenyl]piperazin-1-yl]pentan-2-yl]propanamide
CFAMM00430120 CHEMBL33892 Bioactive 2-amino-N-[(2R)-1-[4-[2-(methanesulfonamido)phenyl]piperazin-1-yl]-1-oxo-5-phenylpentan-2-yl]-2-methylpropanamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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