CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14758
Family Name Epidermal growth factor receptor and Receptor tyrosine-protein kinase erbB-2 ligand N-[4-(3-chloro-4-fluoroanilino)-7-[3-(4-methylpiperazin-1-yl)propoxy]pyrido[3,2-d]pyrimidin-6-yl]prop-2-enamide family
No. of Seeds 8 No. of Other Members 0
Family Centroid CFAMM00331391 Functional Category Bioactive
Superfamily Pol polyprotein and Reverse transcriptase/RNaseH Binder Superfamily
Class Class 2640

Cousin Family NamesSeedsMembers
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Epidermal growth factor receptor and Receptor tyrosine-protein... 9 65
Epidermal growth factor receptor and Receptor tyrosine-protein... 16 89
Receptor tyrosine-protein kinase erbB-2 Inhibitor TAK-285 Family 16 124
Tyrosine-protein kinase Lck inhibitor 4-N-(2-chloro-6-methylph... 8 45
Epidermal growth factor receptor ligand N-[4-(3-chloro-4-fluor... 6 47
Vascular endothelial growth factor receptor 2 and Fibroblast g... 3 11
Vascular endothelial growth factor receptor 2 and Fibroblast g... 10 3
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
Vascular endothelial growth factor receptor 2 ligand 1-[4-[6-a... 11 13
Epidermal growth factor receptor and Receptor tyrosine-protein... 6 9
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Insulin receptor and Insulin-like growth factor 1 receptor lig... 17 7
Insulin-like growth factor 1 receptor and Potassium voltage-ga... 2 2
Dual specificity protein kinase TTK inhibitor 6-N-cyclohexyl-2... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 0
Receptor tyrosine-protein kinase erbB-2 ligand N-[3-chloro-4-(... 4 3
Epidermal growth factor receptor ligand SureCN4454332 family 18 5
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 9 2
Epidermal growth factor receptor ligand AGN-PC-078X8C family 10 8
Epidermal growth factor receptor ligand SureCN2989664 family 5 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 10 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00430149 CHEMBL448172 Bioactive AGN-PC-078WZS
CFAMM00430148 CHEMBL490497 Bioactive AGN-PC-078XBV
CFAMM00430147 CHEMBL490498 Bioactive AGN-PC-078XBW
CFAMM00430146 CHEMBL31570 Bioactive N-[4-(3-chloro-4-fluoroanilino)-7-(2-methoxyethoxy)pyrido[3,2-d]pyrimidin-6-yl]prop-2-enamide
CFAMM00430145 CHEMBL489897 Bioactive AGN-PC-078WZQ

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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