CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14785
Family Name Plasmepsin-2 and Cathepsin D inhibitor N-[2-(1,3-benzodioxol-5-yl)ethyl]-N-[(2S,3S)-3-[[2-(3-chlorophenoxy)acetyl]amino]-2-hydroxy-4-phenylbutyl]-1-methylpiperidine-4-carboxamide family
No. of Seeds 4 No. of Other Members 0
Family Centroid CFAMM00430274 Functional Category Bioactive
Superfamily Cathepsin D and Plasmepsin-2 Binder Superfamily 3
Class Class 648

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase PLK1 Inhibitor On Fa... 16 138
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Beta-3 adrenergic receptor Ligand Amibegron Family 8 46
Amine oxidase [flavin-containing] B Inhibitor (r)-n2-{4-[(3-ch... 3 0
Regulator of G-protein signaling 12 and Beta-lactamase inhibit... 1 7
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[(2... 10 12
Cathepsin D inhibitor N-[2-(1,3-benzodioxol-5-yl)ethyl]-N-[(2S... 1 6
Cathepsin K and Cathepsin L1 inhibitor dipeptidyl nitrile, 16c... 1 0
Scytalone dehydratase inhibitor 2-cyano-N-[(1S,2R)-1-(2-cyanop... 5 0
Growth hormone secretagogue receptor type 1 ligand N-benzyl-2-... 5 19


External ID

Functional Category

Molecule Name

CFAMM00430275 CHEMBL33989 Bioactive hydroxyethylamine-based inhibitor 3
CFAMM00430274 CHEMBL285133 Bioactive N-[2-(1,3-benzodioxol-5-yl)ethyl]-N-[(2S,3S)-3-[[2-(3-chlorophenoxy)acetyl]amino]-2-hydroxy-4-phenylbutyl]-1-methylpiperidine-4-carboxamide
CFAMM00430273 CHEMBL290115 Bioactive 1-acetyl-N-[2-(1,3-benzodioxol-5-yl)ethyl]-N-[(2S,3S)-3-[[2-(3-chlorophenoxy)acetyl]amino]-2-hydroxy-4-phenylbutyl]piperidine-4-carboxamide
CFAMM00430276 CHEMBL285177 Bioactive N-[(2S,3S)-3-[[2-(3-chlorophenoxy)acetyl]amino]-2-hydroxy-4-phenylbutyl]-N-[2-(4-methoxyphenyl)ethyl]-1-methylpiperidine-4-carboxamide

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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