CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14814
Family Name Renin and Cathepsin D inhibitor N-[(2S)-1-[[(2S)-1-[[(2S)-1-cyclohexyl-4,4-difluoro-5-(2-morpholin-4-ylethylamino)-3,5-dioxopentan-2-yl]amino]-1-oxopent-4-en-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]morpholine-4-carboxamide family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00343558 Functional Category Bioactive
Superfamily Prothrombin Inhibitor Ximelagatran Superfamily
Class Class 608

Cousin Family NamesSeedsMembers
Angiotensin-converting enzyme Inhibitor Quinapril Family 3 105
Bacterial outer membrane Inhibitor Polymyxin B Family 17 181
20S proteasome Inhibitor Carfilzomib Family 5 17
Renin Inhibitor CP-80794 Family 16 112
Cathepsin F and Cruzipain Inhibitor WRR-99 Family 13 131
Beta-secretase 1 Inhibitor MMI-175 Family 30 137
Disintegrin and metalloproteinase domain-containing protein 17... 8 7
Plasmepsin-2 Inhibitor PS-222036 Family 12 134
Plasmepsin-1 Inhibitor SC-5003 Family 93 173
Beta-secretase 1 Inhibitor Glu-leu-asp-leu-(choh-ch2)-ala-ala-... 15 11
Calcitonin gene-related peptide type 1 receptor Ligand Fvptdvg... 8 8
Melanocortin receptor 4 and Substance-K receptor Ligand Hoo-ph... 3 19
Beta-secretase 1 Inhibitor KMI-172 Family 3 0
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 6 24
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Integrin alpha-V Inhibitor C[rgdf-(3s)-carboxymorpholine] Family 10 2
Caspase-4 and Cathepsin D Inhibitor Grassystatin A Family 24 6
Mu-type opioid receptor and Nociceptin receptor Ligand Nocicep... 35 5
Renin inhibitor (2S,4S,5S)-N-butyl-6-cyclohexyl-4-hydroxy-5-[[... 12 1
Renin inhibitor (2S,4S,5S)-N-(4-aminobutyl)-6-cyclohexyl-4-hyd... 32 2
Renin and Cathepsin D inhibitor (2S)-N-[(2S,3R,4S)-1-cyclohexy... 13 2
Renin inhibitor tert-butyl N-[1-[[(3S,6S,7R)-6-(cyclohexylmeth... 14 1
Cathepsin B and Calpain-2 catalytic subunit inhibitor AGN-PC-0... 2 2
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 1 8
Renin and Cathepsin D inhibitor (3S)-4-[[6-acetamido-2-[[3-nap... 6 26
Renin and Cathepsin D inhibitor tert-butyl N-[(2S)-1-[[(2S)-1-... 3 4
Melanocortin receptor 4 and Melanocortin receptor 5 ligand (2S... 16 24
Melanocortin receptor 4 and Melanocortin receptor 5 ligand AC1... 7 31
Dipeptidyl peptidase 4 inhibitor (3R)-4-[(3R)-3-amino-4-(2,4,5... 6 6
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 16 1
Pol polyprotein inhibitor AC1LADQG family 7 1
Endothelin-converting enzyme 1 and Cathepsin D inhibitor N-[(2... 6 2
Beta-secretase 1 inhibitor (2S)-2-[(3R)-3-acetamido-3-(2-methy... 3 0
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 6 11
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 13 3
Renin inhibitor N-[(3S)-5-[2-(2-aminoethyl)morpholin-4-yl]-1-c... 4 2
Renin inhibitor AGN-PC-076HPD family 1 0
Beta-secretase 1 and Cathepsin D inhibitor (4S)-N-[(2S,3R)-4-[... 3 0
Cathepsin E and Renin inhibitor (2S)-N-[2-[[(2S,3S,5S)-1-cyclo... 4 0
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 15 0
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 2 0
Renin and Cathepsin D inhibitor ethyl (4S)-5-cyclohexyl-2,2-di... 2 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 10 0
Pol polyprotein inhibitor 4-benzyl-N-[(2S)-1-[[(2S,3R,4S,5S)-5... 3 0
Pol polyprotein inhibitor Diol-Based HIV-1 protease inhibitor ... 1 0
Renin inhibitor N-[(2S)-1-[[(2R)-1-[[(2S)-3-cyclohexyl-1-dimet... 3 1
Pol polyprotein inhibitor AC1LACBC family 2 0
Melanocortin receptor 4 and Melanocortin receptor 3 ligand (2S... 2 0
Beta-secretase 1 inhibitor SureCN8292004 family 1 0
Renin inhibitor (2S)-2-[(2S)-1-(azetidin-1-yl)-1-oxo-3-phenylp... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00430437 CHEMBL32575 Bioactive N-[(2S)-1-[[(2S)-1-[[(2S)-1-cyclohexyl-4,4-difluoro-3-hydroxy-5-(2-morpholin-4-ylethylamino)-5-oxopentan-2-yl]amino]-1-oxopent-4-en-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]morpholine-4-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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