CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14817
Family Name Renin inhibitor (1R,2R,3S)-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-2-phenyl-3-propan-2-ylsulfonylcyclopropane-1-carboxamide family
No. of Seeds 5 No. of Other Members 0
Family Centroid CFAMM00430476 Functional Category Bioactive
Superfamily Renin and Pol polyprotein Binder Superfamily
Class Class 168

Cousin Family NamesSeedsMembers
Angiotensin-converting enzyme Inhibitor Spirapril Family 17 86
Renin Inhibitor CP-80794 Family 16 112
Beta-secretase 1 Inhibitor MMI-175 Family 30 137
Plasmepsin-1 Inhibitor SC-5003 Family 93 173
Protein farnesyltransferase subunit beta Inhibitor L-739750 Fa... 4 0
Pol polyprotein inhibitor 169168-45-0 family 7 11
Pol polyprotein inhibitor 169273-51-2 family 10 0
Pol polyprotein inhibitor AC1LA3TO family 8 0
Renin and Cathepsin D inhibitor (2S)-N-[(2S,3R,4S)-1-cyclohexy... 13 2
Pol polyprotein inhibitor Lysine Sulfonamide 11c family 3 73
Pol polyprotein inhibitor benzyl N-[(2S,3R)-4-[(3aR,6S,7aS)-6-... 3 2
Matrix metalloproteinase-9 and Stromelysin-1 inhibitor N-[(2S)... 1 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-cycl... 1 6
Pol polyprotein inhibitor Sulfone deriv. 31 family 15 4
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 3 3
Beta-secretase 1 and Cathepsin B inhibitor SureCN4666465 family 9 4
Cathepsin E and Renin inhibitor (2S)-N-[2-[[(2S,3S,5S)-1-cyclo... 4 0
Beta-secretase 1 and Cathepsin B inhibitor 3-chloro-N-[(2S)-1-... 2 0
Pol polyprotein inhibitor AC1LAH8S family 11 1
Renin inhibitor tert-butyl N-[1-[[1-[[(2S,3R)-1-cyclohexyl-3-h... 2 0
Pol polyprotein inhibitor AC1LACBC family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00430476 CHEMBL286245 Bioactive (1R,2R,3S)-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-2-phenyl-3-propan-2-ylsulfonylcyclopropane-1-carboxamide
CFAMM00430475 CHEMBL443253 Bioactive (1R,2R,3S)-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]amino]-1-oxohexan-2-yl]-2-phenyl-3-propan-2-ylsulfonylcyclopropane-1-carboxamide
CFAMM00430474 CHEMBL328238 Bioactive (2S)-2-[[(2S)-2-benzyl-3-tert-butylsulfonylpropanoyl]amino]-N-[(2S,3R,4R)-5-(butylsulfamoyl)-1-cyclohexyl-3,4-dihydroxypentan-2-yl]-4-methylpentanamide
CFAMM00430473 CHEMBL29948 Bioactive (1S,2S,3R)-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]amino]-1-oxohexan-2-yl]-2-phenyl-3-propan-2-ylsulfonylcyclopropane-1-carboxamide
CFAMM00430472 CHEMBL31121 Bioactive (1S,2S,3R)-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-2-phenyl-3-propan-2-ylsulfonylcyclopropane-1-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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