CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14827
Family Name 72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-[(2S)-3-cyclohexyl-1-oxo-1-[2-(4-sulfamoylphenyl)ethylamino]propan-2-yl]-N'-hydroxy-2-[3-(4-methylphenyl)propyl]butanediamide family
No. of Seeds 7 No. of Other Members 1
Family Centroid CFAMM00228772 Functional Category Bioactive
Superfamily Stromelysin-1 and Carbonic anhydrase 2 Binder Superfamily
Class Class 3217

Cousin Family NamesSeedsMembers
Vasopressin V1a receptor Ligand Felypressin Family 12 820
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
ATP-sensitive inward rectifier potassium channel 10 Ligand Nat... 3 233
Cathepsin K Inhibitor Odanacatib Family 33 84
Melanocortin receptor 4 Ligand Ro-27-3225 Family 6 52
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
72 kDa type IV collagenase Inhibitor Batimastat Family 6 52
Suppressor of tumorigenicity 14 protein and Prothrombin Inhibi... 4 126
Proto-oncogene tyrosine-protein kinase Src Inhibitor RU83876 F... 3 51
Thymidylate synthase Inhibitor N-[tosyl-d-prolinyl]amino-ethan... 1 10
Carbonic anhydrase 2 Inhibitor N-benzyl-4-sulfamoyl-benzamide ... 12 44
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Disintegrin and metalloproteinase domain-containing protein 17... 8 7
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 2-valp... 8 5
Cathepsin B and Cathepsin S Inhibitor Ac-hphe-leu-ala-leuvsme ... 17 51
Suppressor of tumorigenicity 14 protein Inhibitor 3-tapap Family 15 39
Histone deacetylase 1 and Histone deacetylase 4 Inhibitor Azum... 3 10
Disintegrin and metalloproteinase domain-containing protein 17... 7 39
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-(2-p... 6 19
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Aminopeptidase N Inhibitor N1,2-dibenzyl-n3-hydroxymalonamide ... 5 23
Aminopeptidase N Inhibitor 2-benzyl-n1-hydroxy-n3-(4-phenylbut... 5 3
Aminopeptidase N Inhibitor N1-(4-chlorobenzyl)-2-benzyl-n3-hyd... 9 86
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
Aminopeptidase N Inhibitor 2-cinnamamido-n4-hexyl-n1-hydroxysu... 24 8
Calpain Inhibitor SJA-6017 Family 2 12
Trypsin Inhibitor Benzamidrazone Analogue Family 16 6
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 6
72 kDa type IV collagenase and Matrilysin inhibitor (2S,3R)-N-... 1 0
Calpain-1 catalytic subunit inhibitor 6-chloro-2-methyl-1,1-di... 3 9
Cathepsin L1 and Cathepsin B inhibitor (2S)-3-methyl-N-[(2S)-4... 7 24
Pol polyprotein inhibitor Lysine Sulfonamide 11c family 3 73
Neutrophil collagenase and Stromelysin-1 inhibitor AGN-PC-044L... 6 7
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 6 1
Disintegrin and metalloproteinase domain-containing protein 17... 6 5
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 2 7
Peptide deformylase inhibitor (2R)-N-[(2S)-1-(4-fluorophenyl)-... 4 0
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN6368512 f... 23 21
Matrix metalloproteinase-9 and Stromelysin-1 inhibitor N-[(2S)... 1 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 4
Carbonic anhydrase 12 and Carbonic anhydrase 2 inhibitor AGN-P... 5 0
Carbonic anhydrase 2 and Carbonic anhydrase 4 inhibitor 2-[2-[... 10 5
C-C chemokine receptor type 5 ligand N-[(1S)-3-[4-[[2-(2,4-dic... 4 9
Kappa-type opioid receptor and Delta-type opioid receptor liga... 9 0
Collagenase 3 and 72 kDa type IV collagenase inhibitor (2R)-N-... 10 1
Bifunctional epoxide hydrolase 2 inhibitor N-cycloheptyl-1-(2,... 7 8
B1 bradykinin receptor ligand N-[(4S)-1-ethyl-3,3-dimethylpipe... 10 4
Proteasome subunit beta type-5 inhibitor (2S)-N'-(2,2-dimethyl... 2 9
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 4
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-2-... 6 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2S,4R)... 5 8
Neutrophil elastase inhibitor 1-[(2S)-3-methyl-2-(naphthalen-2... 3 1
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 10 0
Coagulation factor X inhibitor ethyl 2-[[(3S)-3-[[2-[[(2R)-2-(... 4 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor methyl ... 6 2
Disintegrin and metalloproteinase domain-containing protein 17... 2 0
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 1 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor (3R)-3-... 3 2
Growth hormone secretagogue receptor type 1 ligand [(3S)-3-ami... 2 6
Neutrophil collagenase and Interstitial collagenase inhibitor ... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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