CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14828
Family Name Matrix metalloproteinase-9 and Collagenase 3 inhibitor N-hydroxy-4-[(4-methoxyphenyl)sulfonyl-(pyridin-3-ylmethyl)amino]-1,3-dimethylpyrazolo[3,4-b]pyridine-5-carboxamide family
No. of Seeds 6 No. of Other Members 2
Family Centroid CFAMM00311314 Functional Category Bioactive
Superfamily Collagenase 3 and Matrix metalloproteinase-9 Binder Superfamily 3
Class Class 979

Cousin Family NamesSeedsMembers
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Serine/threonine-protein kinase PLK1 Inhibitor HMN-214 Family 3 58
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 28
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1
Calmodulin-domain protein kinase 1 and Tyrosine-protein kinase... 5 5
Tyrosine-protein kinase JAK2 inhibitor (2S)-1-[4-[4-[[7-(2-met... 11 27
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 9
Vascular endothelial growth factor receptor 2 ligand AGN-PC-04... 8 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Matrix metalloproteinase-9 and Collagenase 3 inhibitor N-hydro... 2 1
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 4 4
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 7 5
Neuropeptide Y receptor type 5 ligand AGN-PC-074HY0 family 1 0


External ID

Functional Category

Molecule Name

CFAMM00430501 CHEMBL429336 Bioactive N-hydroxy-4-[(4-methoxyphenyl)sulfonyl-(pyridin-3-ylmethyl)amino]-3-methyl-1-phenylpyrazolo[3,4-b]pyridine-5-carboxamide
CFAMM00430500 CHEMBL33980 Bioactive N-hydroxy-4-[(4-methoxyphenyl)sulfonyl-(pyridin-3-ylmethyl)amino]-1-phenylpyrazolo[3,4-b]pyridine-5-carboxamide
CFAMM00430499 CHEMBL286848 Bioactive 4-[[4-(4-chlorophenoxy)phenyl]sulfonyl-methylamino]-N-hydroxy-1,3-dimethylpyrazolo[3,4-b]pyridine-5-carboxamide
CFAMM00430498 CHEMBL38180 Bioactive N-hydroxy-1,3-dimethyl-4-[methyl-(4-pyridin-4-yloxyphenyl)sulfonylamino]pyrazolo[3,4-b]pyridine-5-carboxamide

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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