CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14851
Family Name Pol polyprotein inhibitor N-[2-Hydroxy-2-(8-Isopropyl-6,9-Dioxo-2-Oxa-7,10-Diaza-Bicyclo[11.2.2]Heptadeca-1(16),13(17),14-Trien-11-Yl)-Ethyl]-N-(3-Methyl-Butyl)-Benzenesulfonamide,Inhibitor 3 family
No. of Seeds 7 No. of Other Members 6
Family Centroid CFAMM00430650 Functional Category Bioactive
Superfamily Pol polyprotein and Collagenase 3 Binder Superfamily
Class Class 3387

Cousin Family NamesSeedsMembers
Glycoprotein IIb/IIIa receptor Ligand Tirofiban Family 4 173
HIV-1 protease Inhibitor Lopinavir Family 4 25
Thymopentin family 20 133
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Plitidepsin family 15 5
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
Plasmepsin-2 Inhibitor KNI-727 Family 3 37
Vasopeptidase Inhibitor Sampatrilat Family 25 9
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Voltage-dependent N-type calcium channel subunit alpha-1B Liga... 2 2
Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family 11 13
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Disintegrin and metalloproteinase domain-containing protein 17... 82 411
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-il... 36 12
Oxytocin receptor Ligand [mpa1, D-tyr(et)2, D-tic7]ot Family 43 26
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 49 19
Mu-type opioid receptor Ligand H-tyr-d-ala-aic-asp-val-val-gly... 48 8
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Pol polyprotein inhibitor 180968-31-4 family 8 13
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 3 13
Matrilysin and 72 kDa type IV collagenase inhibitor (3S,6R,7S)... 2 2
Disintegrin and metalloproteinase domain-containing protein 17... 10 39
Histamine H3 receptor ligand SureCN4319687 family 8 15
Collagenase 3 and Interstitial collagenase inhibitor N-hydroxy... 8 4
Cathepsin K inhibitor SureCN6578603 family 1 3
Pol polyprotein inhibitor morpholinone scaffold 1 family 5 29
Neprilysin and Angiotensin-converting enzyme inhibitor AGN-PC-... 3 7
Pol polyprotein inhibitor benzyl (2S)-2-[[[(2S)-3-[cyclopentyl... 2 6
Pol polyprotein inhibitor AC1LAPRV family 13 7
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 6 1
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 6 1
Pol polyprotein inhibitor AC1LAGJO family 6 1
Neutrophil collagenase and Stromelysin-1 inhibitor AGN-PC-075O... 14 27
Pol polyprotein inhibitor AC1LA9K7 family 7 23
72 kDa type IV collagenase and Collagenase 3 inhibitor (2R,4S)... 3 0
Pol polyprotein inhibitor AC1NQUJL family 10 11
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-ethy... 7 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(4S)-3... 3 24
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6S... 1 0
Disintegrin and metalloproteinase domain-containing protein 17... 6 12
Disintegrin and metalloproteinase domain-containing protein 17... 25 5
Collagenase 3 and A disintegrin and metalloproteinase with thr... 10 19
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 6 3
Collagenase 3 and 72 kDa type IV collagenase inhibitor (2R)-2-... 4 6
Collagenase 3 and 72 kDa type IV collagenase inhibitor (2R)-2-... 2 0
Pol polyprotein inhibitor MDL 74538 family 11 1
Kappa-type opioid receptor and Cytochrome P450 2D6 ligand N-[(... 1 0
Angiotensin-converting enzyme and Neprilysin inhibitor (2S,5R)... 15 3
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 7 1
Matrix metalloproteinase-9 and Neutrophil collagenase inhibito... 3 0
Angiotensin-converting enzyme 2 and Neprilysin inhibitor (2S)-... 6 1
72 kDa type IV collagenase and Neutrophil collagenase inhibito... 12 20
Renin inhibitor (3S,6R)-6-(cyclohexylmethyl)-7-hydroxy-7-[[(2S... 1 0
Pol polyprotein inhibitor AC1L9X2E family 1 2
Calpain-1 catalytic subunit inhibitor 2-ethyl-1,1-dioxo-N-[(2S... 4 30
Integrin beta-1 and Integrin alpha-4 inhibitor (2R)-3-[4-(2-me... 18 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2-me... 4 0
Disintegrin and metalloproteinase domain-containing protein 17... 2 0
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN6429531 f... 2 0
Disintegrin and metalloproteinase domain-containing protein 17... 13 1
72 kDa type IV collagenase and Collagenase 3 inhibitor 2-[(3Z)... 4 3
72 kDa type IV collagenase and Collagenase 3 inhibitor SureCN7... 5 2
Cathepsin S and Cathepsin L1 inhibitor benzyl N-[(2S)-1-oxo-1-... 2 2
Pol polyprotein inhibitor (3S)-N-tert-butyl-2-[(2R)-2-[(3S,6S,... 3 1
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 0
Neutrophil collagenase and Interstitial collagenase inhibitor ... 3 0
Collagenase 3 and Disintegrin and metalloproteinase domain-con... 2 0
Renin inhibitor ethyl N-[1-[[1-[[(2S,3R,4S)-1-cyclohexyl-3,4-d... 2 0
Renin inhibitor (2S,4S,5S,7S)-5-amino-4-hydroxy-7-[[4-methoxy-... 2 0
72 kDa type IV collagenase and Collagenase 3 inhibitor AGN-PC-... 4 0
72 kDa type IV collagenase and Interstitial collagenase inhibi... 2 0
Caspase-1 inhibitor 3-[[(2S)-4-hydroxy-1-[(2S)-3-methyl-2-[[(E... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00430651 CHEMBL288836 Bioactive AC1LAEPI
CFAMM00430644 CHEMBL295464 Bioactive N-[(2R)-2-[(3S,6S)-5,8-dioxo-6-propan-2-yl-14-oxa-4,7-diazabicyclo[13.2.2]nonadeca-1(17),15,18-trien-3-yl]-2-hydroxyethyl]-N-(3-methylbutyl)benzenesulfonamide
CFAMM00430650 CHEMBL288010 Bioactive N-[2-Hydroxy-2-(8-Isopropyl-6,9-Dioxo-2-Oxa-7,10-Diaza-Bicyclo[11.2.2]Heptadeca-1(16),13(17),14-Trien-11-Yl)-Ethyl]-N-(3-Methyl-Butyl)-Benzenesulfonamide,Inhibitor 3
CFAMM00430643 CHEMBL316144 Bioactive N-[(2R)-2-[(3R,6S)-5,8-dioxo-6-propan-2-yl-12-oxa-4,7-diazabicyclo[11.2.2]heptadeca-1(15),13,16-trien-3-yl]-2-hydroxyethyl]-N-(3-methylbutyl)benzenesulfonamide
CFAMM00430647 CHEMBL296937 Bioactive N-[(2R)-2-[(3S,6S)-5,8-dioxo-6-propan-2-yl-14-oxa-4,7-diazabicyclo[13.2.2]nonadeca-1(17),15,18-trien-3-yl]-2-hydroxyethyl]-N-(3-methylbutyl)naphthalene-2-sulfonamide
CFAMM00430646 CHEMBL45135 Bioactive (3S,6S)-3-[(1R)-2-[benzenesulfonyl(3-methylbutyl)amino]-1-hydroxyethyl]-5,8-dioxo-12-oxa-4,7-diazabicyclo[11.2.2]heptadeca-1(15),13,16-triene-6-carboxamide
CFAMM00430645 CHEMBL83186 Bioactive 2-[(3R,6S)-3-[(1R)-2-[benzenesulfonyl(3-methylbutyl)amino]-1-hydroxyethyl]-5,8-dioxo-12-oxa-4,7-diazabicyclo[11.2.2]heptadeca-1(15),13,16-trien-6-yl]acetamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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