CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14853
Family Name cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor N-[3-(1-ethyl-3-methyl-4-oxo-2H-pyrazolo[3,4-d]pyrimidin-6-yl)-4-propoxyphenyl]acetamide family
No. of Seeds 26 No. of Other Members 6
Family Centroid CFAMM00061500 Functional Category Bioactive
Superfamily Prelamin-A/C and Menin Binder Superfamily 4
Class Class 851

Cousin Family NamesSeedsMembers
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Vardena... 3 39
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Sildena... 17 40
Extracellular calcium-sensing receptor ligand (5R)-N-[3-(4-eth... 6 7
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A ... 1 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 1,3-dim... 3 8
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN7... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase and Calcium/calmo... 2 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 1,3-dim... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor (5Z)-1-... 1 0


External ID

Functional Category

Molecule Name

CFAMM00430653 CHEMBL43862 Bioactive ethyl N-[[3-(1,3-dimethyl-4-oxo-2H-pyrazolo[3,4-d]pyrimidin-6-yl)-4-propoxyphenyl]carbamothioyl]carbamate
CFAMM00430658 CHEMBL290402 Bioactive 1,3-dimethyl-6-(5-nitro-2-propoxyphenyl)-2H-pyrazolo[3,4-d]pyrimidin-4-one
CFAMM00430664 CHEMBL43320 Bioactive 3-methyl-6-(2-propoxyphenyl)-1-(2,2,2-trifluoroethyl)-2H-pyrazolo[3,4-d]pyrimidin-4-one
CFAMM00430657 CHEMBL298295 Bioactive 1-ethyl-3-methyl-6-(5-nitro-2-propoxyphenyl)-2H-pyrazolo[3,4-d]pyrimidin-4-one
CFAMM00430663 CHEMBL46771 Bioactive SureCN7299016
CFAMM00430656 CHEMBL361736 Bioactive 6-(2-ethoxyphenyl)-3-methyl-1-propyl-2H-pyrazolo[3,4-d]pyrimidin-4-one
CFAMM00430662 CHEMBL42776 Bioactive 6-[5-(dimethylamino)-2-propoxyphenyl]-1-ethyl-3-methyl-2H-pyrazolo[3,4-d]pyrimidin-4-one
CFAMM00430655 CHEMBL295224 Bioactive 6-[5-[(5-amino-1H-1,2,4-triazol-3-yl)amino]-2-propoxyphenyl]-1,3-dimethyl-2H-pyrazolo[3,4-d]pyrimidin-4-one

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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