CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14877
Family Name Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ligand 3-[2-(6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl)ethyl]-1,5-dihydropyrimido[5,4-b]indole-2,4-dione family
No. of Seeds 1 No. of Other Members 1
Family Centroid CFAMM00430794 Functional Category Bioactive with Natural Product
Superfamily Signal transducer and Cellular tumor antigen p53 Binder Superfamily
Class Class 3172

Cousin Family NamesSeedsMembers
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Cyclooxygenase Inhibitor Indomethacin Family 6 271
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
Adenosine receptor A1 and Adenosine receptor A3 Ligand 4-metho... 1 16
Alpha-1A adrenergic receptor Ligand A-131701 Family 16 17
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
Platelet-derived growth factor receptor alpha and Platelet-der... 4 54
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-366... 5 75
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
Sigma non-opioid intracellular receptor 1 and Kappa-type opioi... 3 12
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 7 44
Disintegrin and metalloproteinase domain-containing protein 17... 14 9
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 9 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 14
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Disintegrin and metalloproteinase domain-containing protein 17... 2 8
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Receptor-type tyrosine-protein kinase FLT3 and Vascular endoth... 4 4
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 2 21
Disintegrin and metalloproteinase domain-containing protein 17... 4 1
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 52 12
Adenosine receptor A2b and Adenosine receptor A1 ligand MRS 17... 10 0
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 2 15
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... 2 2
D(3) dopamine receptor ligand N-[4-[4-(2,3-dichlorophenyl)pipe... 3 15
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 21
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 5
Histone deacetylase 3 and Histone deacetylase 9 inhibitor (3S,... 1 16
D(2) dopamine receptor and Alpha-1B adrenergic receptor ligand... 3 4
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 19 10
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 8 4
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... 11 12
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Platelet-derived growth factor receptor alpha and Vascular end... 3 1
Beta-2 adrenergic receptor ligand SureCN4598646 family 7 7
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... 1 3
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
Disintegrin and metalloproteinase domain-containing protein 17... 5 4
Bifunctional epoxide hydrolase 2 inhibitor 8-(quinoline-5-carb... 1 0
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 3 4
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 1
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Mu-type opioid receptor ligand MITRAGYNINE family 2 8
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 2 1
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 9
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 4 1
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL4... 6 2
Adenosine receptor A2b and Adenosine receptor A1 ligand [4-(2,... 6 15
Adenosine receptor A2b and Adenosine receptor A2a ligand SureC... 2 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 1 0
Signal transducer and activator of transcription 1-alpha/beta ... 1 36
Oxysterols receptor LXR-beta ligand indole derivative, 39 family 2 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00430794 CHEMBL288809 Bioactive 3-[2-(6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl)ethyl]-1,5-dihydropyrimido[5,4-b]indole-2,4-dione

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26853 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543