CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14879
Family Name 5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine receptor 1A ligand N-[4-[[5-[3-(2-aminoethyl)-1H-indol-5-yl]-1,2,4-oxadiazol-3-yl]methyl]phenyl]acetamide family
No. of Seeds 8 No. of Other Members 13
Family Centroid CFAMM00412140 Functional Category Bioactive with Natural Product
Superfamily 5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine receptor 6 Binder Superfamily
Class Class 1228

Cousin Family NamesSeedsMembers
Cyclin-dependent kinase 1 and Cyclin-dependent kinase 2 Inhibi... 1 8
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 4 3
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Disintegrin and metalloproteinase domain-containing protein 17... 4 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL2... 3 8
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Platelet-activating factor receptor ligand SureCN7497229 family 4 2
Scavenger receptor class B member 1 ligand methyl 9-[3-(4,6-di... 2 10
Sphingosine 1-phosphate receptor 1 ligand 3-[5-[5-[3,5-bis(tri... 4 6
Sphingosine 1-phosphate receptor 1 ligand 3-(3H-benzimidazol-5... 2 3
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 6 25
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 12 13
Type-1 angiotensin II receptor ligand N-[2-(3-methoxyphenyl)et... 2 0
Platelet-derived growth factor receptor alpha and Vascular end... 3 1
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 3 1
Growth hormone secretagogue receptor type 1 ligand SureCN36800... 14 42
Growth hormone secretagogue receptor type 1 ligand SureCN36380... 6 0
Scavenger receptor class B member 1 ligand 5-[9-[3-(3,5-difluo... 4 2
Scavenger receptor class B member 1 ligand 5-[9-[3-(4,6-dimeth... 7 3
5-hydroxytryptamine receptor 1D ligand N-[4-[[5-[3-[2-(dimethy... 4 16
Scavenger receptor class B member 1 ligand 5-[9-[3-(6-fluoro-1... 1 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Growth hormone secretagogue receptor type 1 ligand N-[(1R)-2-(... 3 2
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 5
5-hydroxytryptamine receptor 1D ligand N-[4-[[5-[[3-(2-aminoet... 8 7
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 16 0
5-hydroxytryptamine receptor 6 ligand 2-[(2Z)-2-[3-[(3-methoxy... 1 11
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 8 6
Histone deacetylase 1 inhibitor (7S)-N-hydroxy-7-[[2-(5-methox... 1 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(9-... 7 4
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-07CPKU family 1 3
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 0
NP 3-(4-isopropoxyphenyl)-n-(2-(5-methoxy-1h-indol-3-yl)ethyl)... 5 0
3-[(2-carbamoylphenoxy)methyl]-N-[2-(1H-indol-3-yl)ethyl]-1,2,... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00430798 CHEMBL40126 Bioactive 2-[5-[3-[(3-methoxyphenyl)methyl]-1,2,4-oxadiazol-5-yl]-1H-indol-3-yl]ethanamine
CFAMM00430803 CHEMBL290657 Bioactive 2-[5-(3-benzyl-1,2,4-oxadiazol-5-yl)-1H-indol-3-yl]-N,N-dimethylethanamine
CFAMM00430809 CHEMBL288880 Bioactive 4-[5-[3-(2-aminoethyl)-1H-indol-5-yl]-1,2,4-oxadiazol-3-yl]-N-methylbenzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27036 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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