CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14883
Family Name 5-hydroxytryptamine receptor 1D ligand N-[4-[[5-[[3-(2-aminoethyl)-1H-indol-5-yl]methyl]-1,2,4-oxadiazol-3-yl]methyl]phenyl]acetamide family
No. of Seeds 8 No. of Other Members 7
Family Centroid CFAMM00430855 Functional Category Bioactive with Natural Product
Superfamily 5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine receptor 6 Binder Superfamily
Class Class 1228

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1D Ligand Rizatriptan Family 7 460
5-hydroxytryptamine receptor Ligand Ramosetron Family 10 219
Growth hormone receptor Ligand EP-51216 Family 34 390
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
NS5A protein Inhibitor Bms 790052 Family 5 9
Vascular endothelial growth factor receptor 2 Ligand XL999 Family 11 87
Platelet activating factor, putative Inhibitor ABT-491 Family 22 62
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Renin Inhibitor Sul-pro-phe-n-mehis-lva-ile-amp Family 47 54
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 4 3
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Prothrombin and Cationic trypsin inhibitor (2S)-N-[(2S)-1-(1H-... 4 15
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 4 4
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 9 10
Coagulation factor X and Coagulation factor IX inhibitor 5-ami... 9 4
Sphingosine 1-phosphate receptor 1 ligand 3-[5-[5-[3,5-bis(tri... 4 6
Sphingosine 1-phosphate receptor 1 ligand 3-(3H-benzimidazol-5... 2 3
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 6 25
Coagulation factor X inhibitor SureCN8289965 family 4 5
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-0733AC family 7 29
Integrin beta-3 and Integrin alpha-V inhibitor SureCN2833591 f... 4 6
Somatostatin receptor type 3 ligand tert-butyl 4-[(3R)-3-(5-ph... 2 2
5-hydroxytryptamine receptor 1D ligand N-[4-[[5-[3-[2-(dimethy... 4 16
Scavenger receptor class B member 1 ligand 5-[9-[3-(6-fluoro-1... 1 4
Somatostatin receptor type 3 and Somatostatin receptor type 4 ... 5 1
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 1
Gonadotropin-releasing hormone receptor ligand 1-[2-(3,5-dimet... 3 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 8 13
Matrilysin and Stromelysin-1 inhibitor (2R)-N-[(1S)-1-(1H-benz... 3 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 3
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(9-... 7 4
Bifunctional epoxide hydrolase 2 and Potassium voltage-gated c... 1 0
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-07CPKU family 1 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00430858 CHEMBL38104 Bioactive 4-[5-[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl]-1,2,4-oxadiazol-3-yl]-N-methylbenzamide
CFAMM00430857 CHEMBL39111 Bioactive 5-[2-[3-(2-aminoethyl)-1H-indol-5-yl]ethyl]-1,2,4-oxadiazol-3-amine
CFAMM00430863 CHEMBL290706 Bioactive N-[4-[[5-[[3-(2-aminoethyl)-1H-indol-5-yl]methyl]-1,2,4-oxadiazol-3-yl]methyl]phenyl]methanesulfonamide
CFAMM00430867 CHEMBL38671 Bioactive N-[4-[5-[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl]-1,2,4-oxadiazol-3-yl]phenyl]methanesulfonamide
CFAMM00430862 CHEMBL288961 Bioactive 2-[5-[3-(3-methyl-1,2,4-oxadiazol-5-yl)propyl]-1H-indol-3-yl]ethanamine
CFAMM00430855 CHEMBL39158 Bioactive N-[4-[[5-[[3-(2-aminoethyl)-1H-indol-5-yl]methyl]-1,2,4-oxadiazol-3-yl]methyl]phenyl]acetamide
CFAMM00430859 CHEMBL37629 Bioactive 2-[5-[3-(3-benzyl-1,2,4-oxadiazol-5-yl)propyl]-1H-indol-3-yl]ethanamine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27759 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543