CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14889
Family Name Epidermal growth factor receptor ligand Pyrroloquinazoline deriv. 4 family
No. of Seeds 7 No. of Other Members 0
Family Centroid CFAMM00430895 Functional Category Bioactive
Superfamily Epidermal growth factor receptor and Lysosomal alpha-glucosidase Binder Superfamily
Class Class 3785

Cousin Family NamesSeedsMembers
Transient receptor potential cation channel subfamily V member... 15 457
Interleukin-12 subunit alpha Inhibitor STA-5326 Family 2 51
Tyrosine-protein kinase JAK2 Inhibitor INCB18424 Family 3 130
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Adenosine receptor A1 Ligand SLV320 Family 6 79
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
GDC-0349 family 44 77
JAK Inhibitor Momelotinib Family 33 83
PF-4217903 family 14 65
Corticotropin-releasing factor receptor 1 Ligand CP-154526 Family 9 29
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Prostaglandin G/H synthase 2 Inhibitor RWJ-67657 Family 3 33
Epidermal growth factor receptor and Receptor tyrosine-protein... 11 138
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Epidermal growth factor receptor Ligand N*4*-(3-bromo-phenyl)-... 7 11
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
Epidermal growth factor receptor Ligand Benzo[g]quinazolin-4-y... 5 3
Epidermal growth factor receptor Ligand (3-bromo-phenyl)-quina... 7 5
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Adenosine receptor A3 and Dual specificity mitogen-activated p... 5 27
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Glycogen synthase kinase-3 beta Inhibitor 4-(5-bromo-1h-indol-... 7 18
Serine/threonine-protein kinase mTOR Inhibitor 4-(2-(1h-indol-... 2 15
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... 3 10
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Adenosine kinase inhibitor GP683 family 12 7
Adenosine kinase inhibitor AGN-PC-074UAJ family 3 10
Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... 3 13
Adenosine kinase inhibitor abt-702 family 14 1
Corticotropin-releasing factor receptor 1 ligand 3-(2-bromo-4-... 13 34
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07ZB89 family 6 13
Aurora kinase A inhibitor AGN-PC-07ZZEH family 2 4
Protein kinase C theta type and Protein kinase C delta type in... 16 8
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 7 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 34 11
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 46 9
Ephrin type-B receptor 4 ligand SureCN3289519 family 4 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 13 10
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Adenosine kinase inhibitor 5-[3-(3-bromophenyl)propyl]-6-[2-(6... 3 0
Epidermal growth factor receptor ligand AGN-PC-076GVG family 8 1
Epidermal growth factor receptor ligand pyrido[4,3-d]pyrimidin... 11 0
Epidermal growth factor receptor ligand AGN-PC-076GXM family 6 0
Serine/threonine-protein kinase B-raf inhibitor SureCN1013857 ... 9 3
Survival motor neuron protein and Menin inhibitor CHEMBL132797... 1 1
Mitogen-activated protein kinase 14 inhibitor AGN-PC-03XQYG fa... 7 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 1 0
Corticotropin-releasing factor receptor 1 ligand 9-(2-bromo-4-... 15 3
Glycogen synthase kinase-3 beta and Dual specificity protein k... 4 5
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 3 3
Mitogen-activated protein kinase 10 and Transcription factor A... 4 4
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 3
Transient receptor potential cation channel subfamily V member... 2 1
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 1 0
Transient receptor potential cation channel subfamily V member... 4 0
Epidermal growth factor receptor ligand (2R,3R)-3-[[4-(3-bromo... 3 0
Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... 5 3
Casein kinase II subunit alpha and Homeodomain-interacting pro... 5 0
Activated CDC42 kinase 1 inhibitor N,N-dimethyl-4-[4-[[(2S)-ox... 4 2
Aurora kinase A and Cyclin-dependent kinase 4 inhibitor 7-cycl... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 2
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 17 0
Scavenger receptor class B member 1 ligand 9-[3-(4,6-diethylpy... 2 0
Urokinase plasminogen activator surface receptor ligand 3-(1H-... 4 0
Serine/threonine-protein kinase ATR and Serine/threonine-prote... 8 10
Serine/threonine-protein kinase mTOR inhibitor 2-[4-[4-[(3S)-3... 3 0
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 16 0
TGF-beta receptor type-2 and Vascular endothelial growth facto... 2 1
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-[(1-... 9 0
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
Cyclin-dependent kinase 1 and Proto-oncogene tyrosine-protein ... 5 13
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 16 7
Epidermal growth factor receptor ligand AGN-PC-076GWD family 2 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Adenosine kinase inhibitor SureCN8248615 family 2 3
Epidermal growth factor receptor ligand AGN-PC-073LJS family 4 0
Epidermal growth factor receptor ligand 4-Anilinopyrido[3,4-d]... 2 0
G2/mitotic-specific cyclin-B2 and Cyclin-dependent kinase 1 in... 2 1
Epidermal growth factor receptor ligand (E)-5-[4-(3-bromoanili... 11 0
Epidermal growth factor receptor ligand (E)-1-[4-(3-bromoanili... 9 0
Metabotropic glutamate receptor 1 ligand AGN-PC-00FV3S family 2 0
Serine/threonine-protein kinase B-raf inhibitor imidazole-base... 2 0
Epidermal growth factor receptor ligand AGN-PC-078X9P family 4 0
CGMP-dependent protein kinase inhibitor AGN-PC-078XQ0 family 1 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
LIM domain kinase 1 and LIM domain kinase 2 inhibitor (2S)-N'-... 9 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 26 0
Adenosine kinase inhibitor AGN-PC-074DKZ family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00430895 CHEMBL36164 Bioactive Pyrroloquinazoline deriv. 4
CFAMM00430894 CHEMBL39715 Bioactive Pyrroloquinazoline deriv. 8
CFAMM00430893 CHEMBL36967 Bioactive Pyrroloquinazoline deriv. 6
CFAMM00430892 CHEMBL416611 Bioactive Pyrroloquinazoline deriv. 3c
CFAMM00430891 CHEMBL40130 Bioactive Pyrroloquinazoline deriv. 3f
CFAMM00430890 CHEMBL289162 Bioactive Pyrroloquinazoline deriv. 3h
CFAMM00430896 CHEMBL289213 Bioactive Pyrroloquinazoline deriv. 9

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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