CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14902
Family Name 5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine receptor 3B ligand 7-(4-methylpiperazin-1-yl)-6H-chromeno[3,4-c]quinoline family
No. of Seeds 3 No. of Other Members 10
Family Centroid CFAMM00430965 Functional Category Bioactive
Superfamily Platelet-derived growth factor receptor Ligand CP-868596 Superfamily
Class Class 976

Cousin Family NamesSeedsMembers
Alpha-1D adrenergic receptor Ligand Terazosin Family 28 638
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Serine/threonine-protein kinase Chk1 and Serine/threonine-prot... 23 121
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 13
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Serine/threonine-protein kinase mTOR Inhibitor AZD8055 Family 2 2
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Tyrosine kinase Inhibitor PKI166 Family 17 198
Peptide deformylase, mitochondrial Inhibitor 5-(4-methoxypheno... 5 61
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
Melanin-concentrating hormone receptor 1 Ligand 8-sec-butoxy-q... 30 39
Melanin-concentrating hormone receptor 1 Ligand Gnf-pf-2322 Fa... 3 95
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Sodium channel protein type 5 subunit alpha Ligand Enecadin Fa... 1 11
Androgen receptor Ligand 11-methyl-6,11-dihydro-5h-benzo[a]car... 7 9
Adenosine receptor A1 and Adenosine receptor A2a ligand NSC658... 8 54
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 3
Cathepsin S and Cathepsin K inhibitor AGN-PC-088VBO family 3 11
Adenosine kinase inhibitor 5-[3-(4-methoxyphenyl)propyl]-6-[2-... 2 11
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 4
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 19 11
Prostaglandin D2 receptor ligand 3-[2-methoxy-6-[2-(4-methoxyp... 2 12
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL13704... 1 7
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 14
Adenosine receptor A1 and Adenosine receptor A2a ligand (6E)-6... 2 2
Methionine--tRNA ligase inhibitor 2-[3-[(2-ethoxy-5-iodo-3-met... 9 32
Tyrosine-protein kinase JAK2 inhibitor 5-(3-methoxyphenyl)-N-[... 2 11
Methionine--tRNA ligase, cytoplasmic and Methionine--tRNA liga... 8 6
Methionine--tRNA ligase inhibitor 2-({3-[(3,5-Dichlorobenzyl)a... 5 7
Methionine--tRNA ligase inhibitor SureCN7818124 family 1 9
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Prostaglandin D2 receptor ligand 2-[3-[2-methoxy-6-[2-(4-metho... 4 12
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Adenosine receptor A3 ligand AGN-PC-08WSLM family 5 22
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 17
Hepatocyte growth factor receptor ligand AGN-PC-08XYVH family 1 1
Cholecystokinin receptor type A ligand AGN-PC-0A9ULH family 8 8
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-09Q7W... 7 3
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 9 10
Corticotropin-releasing factor receptor 1 ligand 6-ethyl-3-met... 6 10
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 8 3
Dihydrofolate reductase inhibitor 7-(3,4-dimethoxyphenyl)-6-me... 1 3
Dihydrofolate reductase inhibitor 7-(2-ethoxynaphthalen-1-yl)-... 3 2
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075FPC ... 6 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 16 19
Poly [ADP-ribose] polymerase 1 inhibitor 4-[1-[3-(4-oxo-1H-qui... 1 3
Sodium-dependent serotonin transporter inhibitor AGN-PC-075G9A... 3 2
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 9 6
Histamine H4 receptor and Histamine H3 receptor ligand 7-(fura... 2 2
Serine/threonine-protein kinase Chk1 inhibitor SureCN6387344 f... 6 11
Lysine--tRNA ligase inhibitor 4-[[[2-(2-piperazin-1-ylpyridin-... 2 1
D(4) dopamine receptor ligand (1Z)-1-hydroxyimino-1-(3-methylp... 1 5
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 6 4
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 4 4
TRAF2 and NCK-interacting protein kinase inhibitor 4-methoxy-3... 4 1
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 2
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[[4... 7 4
C5a anaphylatoxin chemotactic receptor 1 ligand 2-(2,6-diethyl... 3 5
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 2 6
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 4 0
Dihydrofolate reductase inhibitor AGN-PC-001U7R family 3 0
Adenosine receptor A1 and Adenosine receptor A2a ligand 7-meth... 2 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 4 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 23 5
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 3 1
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 6 1
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 1 0
TGF-beta receptor type-1 ligand SureCN373216 family 3 14
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 5 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 4 3
Serine/threonine-protein kinase Chk2 inhibitor (6E)-4-fluoro-6... 3 6
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 2 8
Dihydrofolate reductase inhibitor 5-[3-(3-methoxy-5-morpholin-... 2 0
Nitric oxide synthase, brain and Nitric oxide synthase, induci... 1 8


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00430972 CHEMBL289486 Bioactive (6E)-6-[3-ethenyl-2-(4-methylpiperazin-1-yl)-1H-quinolin-4-ylidene]cyclohexa-2,4-dien-1-one
CFAMM00430965 CHEMBL304193 Bioactive 7-(4-methylpiperazin-1-yl)-6H-chromeno[3,4-c]quinoline
CFAMM00430966 CHEMBL62589 Bioactive 8-(4-methylpiperazin-1-yl)-6,7-dihydro-[1]benzoxepino[4,5-c]quinoline

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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