CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14910
Family Name Gamma-aminobutyric acid receptor subunit pi and GABA theta subunit ligand AGN-PC-00LKCD family
No. of Seeds 14 No. of Other Members 14
Family Centroid CFAMM00431042 Functional Category Bioactive
Superfamily Metabotropic glutamate receptor 5 and Sodium channel protein type 1 subunit alpha Binder Superfamily
Class Class 2568

Cousin Family NamesSeedsMembers
Peptide deformylase, mitochondrial Inhibitor Pyrimethamine Family 10 145
Transient receptor potential cation channel subfamily V member... 16 295
Transient receptor potential cation channel subfamily V member... 15 457
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Reverse transcriptase Inhibitor Dapivirine Family 5 72
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
HCV NS4B protein Inhibitor Clemizole Family 2 43
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Epidermal growth factor receptor Ligand N4-(3-chlorophenyl)qui... 7 39
Metabotropic glutamate receptor 5 Ligand 2-m-tolyl-1,8-naphthy... 7 11
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Mitogen-activated protein kinase kinase kinase 8 and Stromelys... 6 53
Macrophage migration inhibitory factor Inhibitor 4-iodo-6-phen... 5 4
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... 3 10
Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... 5 35
Metabotropic glutamate receptor 5 Ligand 2-(3,5-dichlorophenyl... 2 3
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 2 2
Metabotropic glutamate receptor 5 Ligand 5-(2-m-tolylethynyl)p... 7 49
Metabotropic glutamate receptor 5 Ligand 5-(2-(3-chlorophenyl)... 2 13
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 5 0
Dihydrofolate reductase inhibitor 6-[[(4-chloronaphthalen-1-yl... 2 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 5 0
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 3 3
Dipeptidyl peptidase 4 inhibitor Aminomethylpyrimidine 1ck family 6 3
Vascular endothelial growth factor receptor 2 and Fibroblast g... 5 2
Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... 4 5
Mitogen-activated protein kinase 14 inhibitor pyrimido-pyrimid... 15 0
Beta-secretase 1 and Potassium voltage-gated channel subfamily... 3 4
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Adenosine kinase inhibitor 5-(4-bromophenyl)-6-[2-[4-(dimethyl... 1 0
Adenosine kinase inhibitor 4-[2-[5-(4-chlorophenyl)-6-piperazi... 3 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 6 3
Cytochrome P450 3A4 and Cytochrome P450 2C8 inhibitor N-[3-[(1... 1 0
Mitogen-activated protein kinase 10 inhibitor CYCLOPROPYL-{4-[... 2 1
Nociceptin receptor and Potassium voltage-gated channel subfam... 5 2
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 7 2
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 1 6
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 7 0
Nociceptin receptor and Mu-type opioid receptor ligand 2-(3-ch... 2 0
Nociceptin receptor and Mu-type opioid receptor ligand (1S,5S)... 1 0
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 2
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-(2-c... 2 0
Nitric oxide synthase, inducible inhibitor N-(3-chlorophenyl)-... 1 0
Vascular endothelial growth factor receptor 2 and Cyclin-depen... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00431050 CHEMBL43683 Bioactive AGN-PC-00LKC5
CFAMM00431042 CHEMBL39418 Bioactive AGN-PC-00LKCD
CFAMM00431035 CHEMBL41816 Bioactive SureCN7969071
CFAMM00431048 CHEMBL289742 Bioactive AGN-PC-00LKC9
CFAMM00431041 CHEMBL296578 Bioactive AGN-PC-00LKCL
CFAMM00431034 CHEMBL289774 Bioactive AGN-PC-00LKCJ
CFAMM00431047 CHEMBL40721 Bioactive AGN-PC-00LKC4
CFAMM00431040 CHEMBL44241 Bioactive AGN-PC-00LFHC
CFAMM00431033 CHEMBL40447 Bioactive AGN-PC-00LKCN
CFAMM00431039 CHEMBL44515 Bioactive AGN-PC-00LKCM
CFAMM00431052 CHEMBL40906 Bioactive AG-H-07485
CFAMM00431032 CHEMBL40446 Bioactive AGN-PC-00LKCO
CFAMM00431045 CHEMBL41553 Bioactive AGN-PC-00LKCK
CFAMM00431038 CHEMBL41856 Bioactive SureCN10966856

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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