CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14937
Family Name Gonadotropin-releasing hormone receptor ligand SureCN7905635 family
No. of Seeds 2 No. of Other Members 2
Family Centroid CFAMM00431177 Functional Category Bioactive with Natural Product
Superfamily Beta-2 adrenergic receptor and Peroxisome proliferator-activated receptor gamma Binder Superfamily
Class Class 3172

Cousin Family NamesSeedsMembers
Leutinizing-hormone-releasing hormone inhibitor peptide Leupro... 43 911
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Gastrin/cholecystokinin type B receptor ligand oligopeptide Ce... 35 209
Somatostatin receptor type 2 ligand octapeptide Lanreotide Family 93 156
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
DNA Binder Elliptinium Acetate Family 11 116
Neuromedin-K receptor Ligand Talnetant Family 3 49
Dihydroorotate dehydrogenase Inhibitor Brequinar Family 9 122
Growth hormone receptor Ligand EP-51216 Family 34 390
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 4 42
Cholecystokinin receptor type A Ligand A-71378 Family 77 23
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Lethal factor Inhibitor GM6001 Family 50 435
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 11 41
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Plasminogen and Prothrombin Inhibitor 2-(2-hydroxy-phenyl)-1h-... 3 69
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 11 12
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Oestrogen receptor and Estrogen receptor beta Ligand 4-(3-phen... 5 14
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
Delta-type opioid receptor and Gastrin/cholecystokinin type B ... 19 0
Platelet-derived growth factor receptor alpha and Platelet-der... 4 54
Platelet-derived growth factor receptor alpha and Platelet-der... 2 13
Serine/threonine-protein kinase Chk1 and Wee1-like protein kin... 2 101
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... 14 33
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-366... 5 75
Type-1 angiotensin II receptor Ligand [sar1,tdf3]angii Family 135 2
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 38 35
Endothelin B receptor Ligand IRL-2500 Family 34 87
Androgen receptor Ligand 11-methyl-6,11-dihydro-5h-benzo[a]car... 7 9
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 46 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 6 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 7 11
Prostaglandin E2 receptor EP4 subtype and Prostaglandin D2 rec... 8 17
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 3 28
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 5 0
Vascular endothelial growth factor receptor 2 ligand indolyl q... 4 3
Vascular endothelial growth factor receptor 2 ligand indolyl q... 2 1
NS5B protein inhibitor AC1NQMYG family 6 12
Acetylcholinesterase and Muscarinic acetylcholine receptor M2 ... 2 7
Somatostatin receptor type 5 and Somatostatin receptor type 1 ... 2 8
Renin inhibitor SureCN1144364 family 3 15
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 2 21
Melanin-concentrating hormone receptor 1 and Cytochrome P450 3... 8 2
Cysteinyl leukotriene receptor 1 ligand AGN-PC-075KCE family 5 33
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 1 2
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-3-... 8 3
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
Cannabinoid receptor 2 ligand [(4R,4aS,8aR)-4-hydroxy-4-phenyl... 2 41
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 21
Acetylcholinesterase inhibitor CHEMBL1651140 family 4 4
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-09Q7W... 7 3
NS5B protein inhibitor AGN-PC-00A17Z family 1 23
Histone deacetylase inhibitor (3S,6S,9S,12R)-3-[(2S)-butan-2-y... 1 0
Prostaglandin D2 receptor and Prostacyclin receptor ligand 2-[... 15 2
NS5B protein inhibitor AC1O5AET family 3 1
Renin and Potassium voltage-gated channel subfamily H member 2... 13 11
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... 11 12
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 12 0
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
Coagulation factor VII inhibitor [3-[(5E)-5-(5-carbamimidoyl-1... 3 2
Coagulation factor VII inhibitor AGN-PC-0763KB family 1 1
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 1 1
Transient receptor potential cation channel subfamily V member... 1 5
Beta-2 adrenergic receptor ligand SureCN5346426 family 8 0
Beta-2 adrenergic receptor ligand SureCN4598646 family 7 7
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Coagulation factor X and Urokinase-type plasminogen activator ... 8 10
Mu-type opioid receptor ligand MITRAGYNINE family 2 8
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 6 8
Coagulation factor VII and Tissue factor inhibitor 2-[3-(5-car... 3 2
Coagulation factor X and Prothrombin inhibitor SureCN6434488 f... 3 13
Cannabinoid receptor 1 ligand (4-hydroxynaphthalen-1-yl)-[1-(2... 2 0
Gonadotropin-releasing hormone receptor ligand 2-[2-(4-methoxy... 1 1
Gonadotropin-releasing hormone receptor ligand 4-[2-[[(2S)-2-[... 1 0
KiSS-1 receptor ligand N-[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL4... 6 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 3 2
Peroxisome proliferator-activated receptor gamma ligand AGN-PC... 4 4
Signal transducer and activator of transcription 1-alpha/beta ... 1 36
Mitogen-activated protein kinase 14 inhibitor AGN-PC-08866Z fa... 2 0
Gamma-aminobutyric acid receptor subunit pi and Gamma-aminobut... 1 1
Lutropin-choriogonadotropic hormone receptor ligand 5-[2-(4-te... 1 1
Coagulation factor VII and Tissue factor inhibitor 5-azaindole... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00431177 CHEMBL291201 Bioactive SureCN7905635
CFAMM00431176 CHEMBL49893 Bioactive AGN-PC-073Q7M

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27511 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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