CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14939
Family Name Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ligand 3-[2-[(3aR,9bR)-6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl]ethyl]-6,7-dimethoxy-1H-quinazoline-2,4-dione family
No. of Seeds 4 No. of Other Members 7
Family Centroid CFAMM00282053 Functional Category Bioactive with Natural Product
Superfamily Microtubule-associated protein tau and Alpha-1D adrenergic receptor Binder Superfamily
Class Class 3426

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
Histamine H1 receptor Ligand Tranilast Family 5 125
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Multidrug resistance protein 1 and Multidrug resistance-associ... 3 55
Urotensin-2 receptor Ligand JNJ-28318706 Family 4 227
Amine oxidase [flavin-containing] A and Mitogen-activated prot... 1 71
D(2) dopamine receptor Ligand Epidepride Family 31 66
Integrin beta-1 and Integrin alpha-4 inhibitor (3S)-3-(3,4-dim... 5 61
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 1 7
C-C chemokine receptor type 3 ligand SureCN6705515 family 2 16
C-C chemokine receptor type 3 ligand 1-(3-cyanophenyl)-3-[6-[[... 2 5
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 49 8
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2C lig... 2 2
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 7
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-088O2L family 1 1
Melanin-concentrating hormone receptor 1 and Potassium voltage... 3 6
Growth hormone secretagogue receptor type 1 ligand (2R)-N-(1-b... 11 4
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 23 10
Integrin beta-3 and Integrin alpha-2 inhibitor 3-(4-methoxyphe... 4 6
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 11
Delta-type opioid receptor and Kappa-type opioid receptor liga... 5 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 11 4
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 10 1
Urotensin-2 receptor ligand SureCN2347581 family 10 10
Urotensin-2 receptor ligand SureCN1472946 family 2 0
NP (s)-3-(2,5-dioxo-2,3,4,5-tetrahydro-1h-benzo[e][1,4]diazepi... 3 0


External ID

Functional Category

Molecule Name

CFAMM00431184 CHEMBL58862 Bioactive 3-[2-[(3aR,9bR)-6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl]ethyl]-6,7-dimethoxy-1-methylquinazoline-2,4-dione
CFAMM00431183 CHEMBL293695 Bioactive 3-[2-[(3aR,9bR)-6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl]ethyl]-7,8-dimethoxy-1H-quinazoline-2,4-dione
CFAMM00431182 CHEMBL58956 Bioactive 3-[2-[(3aR,9bR)-6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl]ethyl]-7-methoxy-1H-quinazoline-2,4-dione

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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