CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14944
Family Name Prolyl endopeptidase inhibitor 1-[(4R)-4-(pyrrolidine-1-carbonyl)-1,3-thiazolidin-3-yl]-2-[(2S)-1,2,3,4-tetrahydronaphthalen-2-yl]ethanone family
No. of Seeds 11 No. of Other Members 0
Family Centroid CFAMM00431240 Functional Category Bioactive
Superfamily Prolyl endopeptidase Inhibitor SUAM-1221 Superfamily
Class Class 634

Cousin Family NamesSeedsMembers
Vasopressin V1a receptor Ligand Felypressin Family 12 820
Glutathione S-transferase Inhibitor Praziquantel Family 5 167
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 2 18
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
Substance-P receptor Ligand [sar9,met(o2)11]-sp Family 34 9
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
Prolyl endopeptidase inhibitor SureCN194654 family 3 4
Kappa-type opioid receptor ligand 1-[(2S)-2-(pyrrolidin-1-ylme... 4 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor (2... 1 1
Prolyl endopeptidase inhibitor [(2S)-2-(pyrrolidine-1-carbonyl... 3 0
Prolyl endopeptidase inhibitor SureCN8938628 family 2 0
Histamine H3 receptor ligand [(3aR,6aR)-4-[4-[2-[(2R)-2-methyl... 6 0


External ID

Functional Category

Molecule Name

CFAMM00431249 CHEMBL294367 Bioactive (2S)-1-[(4R)-3-[2-[(2S)-1,2,3,4-tetrahydronaphthalen-2-yl]acetyl]-1,3-thiazolidine-4-carbonyl]pyrrolidine-2-carbonitrile
CFAMM00431242 CHEMBL66258 Bioactive 2-(2,3-dihydro-1H-inden-2-yl)-1-[(4R)-4-(1,3-thiazolidine-3-carbonyl)-1,3-thiazolidin-3-yl]ethanone
CFAMM00431248 CHEMBL65109 Bioactive SureCN8152338
CFAMM00431241 CHEMBL66088 Bioactive (2S)-1-[(4R)-3-[2-(2,3-dihydro-1H-inden-2-yl)acetyl]-1,3-thiazolidine-4-carbonyl]pyrrolidine-2-carbonitrile
CFAMM00431247 CHEMBL291393 Bioactive (2S)-1-[(4R)-3-[2-[(2S)-1,2,3,4-tetrahydronaphthalen-2-yl]acetyl]-1,3-thiazolidine-4-carbonyl]pyrrolidine-2-carbaldehyde
CFAMM00431240 CHEMBL66257 Bioactive 1-[(4R)-4-(pyrrolidine-1-carbonyl)-1,3-thiazolidin-3-yl]-2-[(2S)-1,2,3,4-tetrahydronaphthalen-2-yl]ethanone
CFAMM00431246 CHEMBL65338 Bioactive (2S)-1-[(4R)-3-[2-(2,3-dihydro-1H-inden-2-yl)acetyl]-1,3-thiazolidine-4-carbonyl]pyrrolidine-2-carbaldehyde
CFAMM00431239 CHEMBL62960 Bioactive SureCN2048453
CFAMM00431245 CHEMBL65512 Bioactive (4R)-3-[(4R)-3-[2-[(2S)-1,2,3,4-tetrahydronaphthalen-2-yl]acetyl]-1,3-thiazolidine-4-carbonyl]-1,3-thiazolidine-4-carbaldehyde
CFAMM00431244 CHEMBL304644 Bioactive 2-[(2S)-1,2,3,4-tetrahydronaphthalen-2-yl]-1-[(4R)-4-(1,3-thiazolidine-3-carbonyl)-1,3-thiazolidin-3-yl]ethanone
CFAMM00431243 CHEMBL64240 Bioactive 2-(2,3-dihydro-1H-inden-2-yl)-1-[(2R)-2-(1,3-thiazolidine-3-carbonyl)pyrrolidin-1-yl]ethanone

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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