CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14951
Family Name Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ligand 3-[2-[(3aR,9bR)-6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl]ethyl]-1H-pyrido[2,3-d]pyrimidine-2,4-dione family
No. of Seeds 4 No. of Other Members 1
Family Centroid CFAMM00431310 Functional Category Bioactive
Superfamily DNA ligase Inhibitor 7-(4-methoxyphenyl)pteridine-2,4-diol Superfamily
Class Class 227

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Smoothened homolog Inhibitor LDE225 Family 3 76
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Glucokinase Inhibitor GKA1 Family 2 67
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Alpha-1A adrenergic receptor Ligand A-131701 Family 16 17
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Potassium voltage-gated channel subfamily H member 2 Ligand Be... 22 56
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
Bifunctional epoxide hydrolase 2 Inhibitor N-benzyl-6-(3,3,3-t... 21 62
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 3
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Liver carboxylesterase 1 Inhibitor SM-32504 Family 3 28
Disintegrin and metalloproteinase domain-containing protein 17... 14 9
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 14
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Muscarinic acetylcholine receptor M2 and Muscarinic receptor 3... 4 3
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 3 5
Receptor-type tyrosine-protein kinase FLT3 and Vascular endoth... 4 4
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
Somatostatin receptor type 5 ligand AGN-PC-080TDB family 10 14
Somatostatin receptor type 5 ligand AGN-PC-088VSK family 2 3
Bifunctional epoxide hydrolase 2 inhibitor SureCN3216677 family 4 9
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
Disintegrin and metalloproteinase domain-containing protein 17... 4 1
Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... 2 5
MAP kinase-activated protein kinase 2 inhibitor N-[4-(4-oxospi... 3 0
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Melanin-concentrating hormone receptor 1 ligand 3-[6-[3-(dimet... 14 6
Melanocortin receptor 4 ligand N-[(2R)-3-(2,4-dichlorophenyl)-... 2 2
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
Motilin receptor ligand SureCN2765637 family 1 1
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... 1 3
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
Bifunctional epoxide hydrolase 2 inhibitor 8-(quinoline-5-carb... 1 0
Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... 2 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 8-[(6,7... 6 8
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 4 9
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 1 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 2
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 2 5
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 1 0
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL4... 2 3
Alpha-2C adrenergic receptor and Alpha-2B adrenergic receptor ... 2 2
C-C chemokine receptor type 8 and Potassium voltage-gated chan... 5 1
C-C chemokine receptor type 8 and Potassium voltage-gated chan... 2 1
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 1 0
Signal transducer and activator of transcription 1-alpha/beta ... 1 36
Dipeptidyl peptidase 4 inhibitor 7-amino-6-(aminomethyl)-5-(2-... 2 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 0
NP (e)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisoben... 8 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00431308 CHEMBL432147 Bioactive 3-[2-[(3aR,9bR)-6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl]ethyl]-1H-pyrido[3,4-d]pyrimidine-2,4-dione
CFAMM00431307 CHEMBL294098 Bioactive 3-[2-[(3aR,9bR)-6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl]ethyl]-1,7-dihydropyrrolo[2,3-d]pyrimidine-2,4-dione
CFAMM00431310 CHEMBL60722 Bioactive 3-[2-[(3aR,9bR)-6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl]ethyl]-1H-pyrido[2,3-d]pyrimidine-2,4-dione

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26858 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543