CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14958
Family Name Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ligand 3-[2-[(3aR,9bR)-6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl]ethyl]-1H-quinazoline-2,4-dione family
No. of Seeds 11 No. of Other Members 4
Family Centroid CFAMM00431352 Functional Category Bioactive with Natural Product
Superfamily Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor Binder Superfamily 9
Class Class 3140

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Multidrug resistance protein 1 and Multidrug resistance-associ... 3 55
Urotensin-2 receptor Ligand JNJ-28318706 Family 4 227
D(2) dopamine receptor Ligand Epidepride Family 31 66
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 1 7
Vasopressin V1a receptor and Vasopressin V2 receptor ligand N-... 1 2
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEH3 family 3 16
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 14 12
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 3 13
C-C chemokine receptor type 3 ligand SureCN6705515 family 2 16
C-C chemokine receptor type 3 ligand 1-(3-cyanophenyl)-3-[6-[[... 2 5
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 49 8
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 4
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2C lig... 2 2
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 7
C5a anaphylatoxin chemotactic receptor 1 ligand N-[(4-dimethyl... 1 4
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 0
Melanin-concentrating hormone receptor 1 and Potassium voltage... 3 6
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Growth hormone secretagogue receptor type 1 ligand (2R)-N-(1-b... 11 4
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 23 10
Bifunctional epoxide hydrolase 2 inhibitor 8-(2,6-difluorobenz... 4 1
Bifunctional epoxide hydrolase 2 inhibitor 8-(2-fluoro-5-hydro... 2 0
Somatostatin receptor type 1 and D(4) dopamine receptor ligand... 9 10
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 7 1
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 11
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 7
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 2 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Trypsin-1 inhibitor N-[7-amino-1-[2-(4-carbamoylphenyl)ethylam... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00431356 CHEMBL302203 Bioactive 3-[2-[(3aR,9bR)-6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl]ethyl]-8-methoxy-1H-quinazoline-2,4-dione
CFAMM00431355 CHEMBL60510 Bioactive 3-[2-[(3aR,9bR)-6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl]ethyl]-6,7-dimethyl-1H-quinazoline-2,4-dione
CFAMM00431354 CHEMBL431720 Bioactive 3-[2-[(3aR,9bR)-6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl]ethyl]-7,8-dimethyl-1H-quinazoline-2,4-dione
CFAMM00431347 CHEMBL61225 Bioactive 3-[2-[(3aR,9bR)-6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl]ethyl]-6-methoxy-1H-quinazoline-2,4-dione
CFAMM00431353 CHEMBL62110 Bioactive 3-[2-[(3aR,9bR)-6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl]ethyl]-5-methyl-1H-quinazoline-2,4-dione
CFAMM00431352 CHEMBL61491 Bioactive 3-[2-[(3aR,9bR)-6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl]ethyl]-1H-quinazoline-2,4-dione
CFAMM00431358 CHEMBL61598 Bioactive N-[3-[2-[(3aR,9bR)-6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl]ethyl]-2,4-dioxo-1H-quinazolin-7-yl]acetamide
CFAMM00431351 CHEMBL304215 Bioactive 3-[2-[(3aR,9bR)-6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl]ethyl]-7-nitro-1H-quinazoline-2,4-dione
CFAMM00431357 CHEMBL369154 Bioactive methyl 3-[2-[(3aR,9bR)-6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl]ethyl]-2,4-dioxo-1H-quinazoline-7-carboxylate

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26412 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543