CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14961
Family Name cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 2-[4-cyano-4-(3-cyclopentyloxy-4-ethoxyphenyl)piperidin-1-yl]-N-hydroxyacetamide family
No. of Seeds 11 No. of Other Members 5
Family Centroid CFAMM00431365 Functional Category Bioactive with Natural Product
Superfamily cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-specific 3',5'-cyclic phosphodiesterase 4A Binder Superfamily 2
Class Class 1768

Cousin Family NamesSeedsMembers
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209
D(3) dopamine receptor Ligand U-99194A Family 7 33
M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30


External ID

Functional Category

Molecule Name

CFAMM00431375 CHEMBL65115 Bioactive 2-[4-cyano-4-(3-ethoxy-4-methoxyphenyl)piperidin-1-yl]-N-hydroxyacetamide
CFAMM00431374 CHEMBL63461 Bioactive 2-[4-cyano-4-(4-methoxy-3-propan-2-yloxyphenyl)piperidin-1-yl]-N-hydroxyacetamide
CFAMM00431367 CHEMBL63568 Bioactive (2S)-2-[4-cyano-4-(3-cyclopentyloxy-4-methoxyphenyl)piperidin-1-yl]-N-hydroxypropanamide
CFAMM00431373 CHEMBL65426 Bioactive 2-[4-cyano-4-[3-cyclopentyloxy-4-(difluoromethoxy)phenyl]piperidin-1-yl]-N-hydroxyacetamide
CFAMM00431366 CHEMBL66357 Bioactive 2-[4-cyano-4-(3,4-dimethoxyphenyl)piperidin-1-yl]-N-hydroxyacetamide
CFAMM00431372 CHEMBL64989 Bioactive AGN-PC-03I81R
CFAMM00431365 CHEMBL63028 Bioactive 2-[4-cyano-4-(3-cyclopentyloxy-4-ethoxyphenyl)piperidin-1-yl]-N-hydroxyacetamide
CFAMM00431378 CHEMBL67668 Bioactive 2-[4-cyano-4-(3-cyclopentyloxy-4-methoxyphenyl)piperidin-1-yl]-N-hydroxyacetamide
CFAMM00431377 CHEMBL294494 Bioactive (2R)-2-[4-cyano-4-(3-cyclopentyloxy-4-methoxyphenyl)piperidin-1-yl]-N-hydroxypropanamide
CFAMM00431370 CHEMBL291889 Bioactive 2-[4-cyano-4-(3-cyclobutyloxy-4-methoxyphenyl)piperidin-1-yl]-N-hydroxyacetamide
CFAMM00431376 CHEMBL65114 Bioactive 2-[4-cyano-4-[3-(cyclopropylmethoxy)-4-methoxyphenyl]piperidin-1-yl]-N-hydroxyacetamide

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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