CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14977
Family Name C-C chemokine receptor type 5 ligand dimethyl-[[4-[[7-(4-methylphenyl)-2,3-dihydro-1-benzoxepine-4-carbonyl]amino]phenyl]methyl]-(oxan-4-yl)azanium;iodide family
No. of Seeds 7 No. of Other Members 8
Family Centroid CFAMM00431493 Functional Category Bioactive
Superfamily Estrogen receptor and Histone deacetylase 6 Binder Superfamily
Class Class 1884

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
Alpha-1A adrenergic receptor and D(2) dopamine receptor Ligand... 5 49
Histone deacetylase 2 Inhibitor N-(4-amino-3'-methoxybiphenyl-... 3 49
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Amine oxidase [flavin-containing] B Inhibitor N-methyl-n-pheny... 6 25
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
Cathepsin K inhibitor N-[(2S)-1-(4-methoxyanilino)propan-2-yl]... 11 10
Poly [ADP-ribose] polymerase 1 inhibitor 6-[1-(2,3-dihydro-1,4... 1 30
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 5 0
C5a anaphylatoxin chemotactic receptor 1 ligand N-[(4-dimethyl... 1 4
Prostaglandin D2 receptor 2 ligand SureCN136287 family 1 9
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 3
Histamine H3 receptor ligand 5-[4-[3-[(2R)-2-methylpyrrolidin-... 2 3
Sphingosine 1-phosphate receptor 1 ligand 2-methoxy-N-[(4-phen... 2 23
Free fatty acid receptor 1 ligand 3-[4-[[3-[4-(2-ethylsulfonyl... 5 4
Integrin beta-3 and Integrin alpha-2 inhibitor 3-(4-methoxyphe... 4 6
Capsid scaffolding protein inhibitor AC1MHP1L family 3 6
Glucagon receptor and Adenylate cyclase type 1 ligand AGN-PC-0... 3 1
D(3) dopamine receptor ligand rac S 33138 family 1 0
Mitogen-activated protein kinase 14 inhibitor SureCN4822166 fa... 1 4
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 5 5
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-04UTCQ fa... 2 1
Estrogen receptor and Histone deacetylase 6 ligand N-[4-[[2-[4... 1 1
3-oxo-5-alpha-steroid 4-dehydrogenase 1 inhibitor AGN-PC-04F7M... 1 3
7,9-dihydrofuro[2,3-f][1,3]benzoxazin-3-one NP ZINC13719463 Fa... 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00431489 CHEMBL61208 Bioactive dimethyl-[[4-[[7-(4-methylphenyl)-2,3-dihydro-1-benzoxepine-4-carbonyl]amino]phenyl]methyl]-(thian-4-yl)azanium;iodide
CFAMM00431482 CHEMBL62598 Bioactive dimethyl-[[4-[[7-(4-methylphenyl)-2,3-dihydro-1-benzoxepine-4-carbonyl]amino]phenyl]methyl]-(4-oxocyclohexyl)azanium;iodide
CFAMM00431488 CHEMBL56565 Bioactive dimethyl-(oxan-4-yl)-[[4-[[7-[4-(trifluoromethyl)phenyl]-2,3-dihydro-1-benzoxepine-4-carbonyl]amino]phenyl]methyl]azanium;iodide
CFAMM00431494 CHEMBL294501 Bioactive 3-hydroxypropyl-dimethyl-[[4-[[7-(4-methylphenyl)-2,3-dihydro-1-benzoxepine-4-carbonyl]amino]phenyl]methyl]azanium;iodide
CFAMM00431480 CHEMBL293393 Bioactive [4-[[7-(4-ethoxyphenyl)-2,3-dihydro-1-benzoxepine-4-carbonyl]amino]phenyl]methyl-dimethyl-(oxan-4-yl)azanium;iodide
CFAMM00431493 CHEMBL292548 Bioactive dimethyl-[[4-[[7-(4-methylphenyl)-2,3-dihydro-1-benzoxepine-4-carbonyl]amino]phenyl]methyl]-(oxan-4-yl)azanium;iodide
CFAMM00431490 CHEMBL294788 Bioactive dimethyl-[[4-[[7-(4-methylphenyl)-2,3-dihydro-1-benzoxepine-4-carbonyl]amino]phenyl]methyl]-pentan-3-ylazanium;iodide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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