CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1498
Family Name Cathepsin K inhibitor [1-(3-methoxyphenyl)-2-methylpropan-2-yl] N-[(2S)-1-oxohexan-2-yl]carbamate family
No. of Seeds 2 No. of Other Members 10
Family Centroid CFAMM00324242 Functional Category Bioactive with Natural Product
Superfamily Cannabinoid receptor 1 Binder Superfamily 2
Class Class 184

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Acetylcholinesterase Inhibitor Rivastigmine Family 2 59
Alpha-1 adrenergic receptor ligand Dextroamphetamine derivativ... 5 29
Glycoprotein IIb/IIIa receptor Ligand Tirofiban Family 4 173
Zucapsacin family 7 177
Thymopentin family 20 133
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Cathepsin F and Cruzipain Inhibitor Benzoyl-arginine-alanine-m... 49 348
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
Voltage-dependent N-type calcium channel subunit alpha-1B Liga... 2 2
Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family 11 13
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Cathepsin B and Cathepsin K Inhibitor Z-ala-leu-tyr(me)-agly-i... 2 1
Neuromedin-K receptor Ligand PD-160946 Family 10 32
Cathepsin B and Cathepsin L1 Inhibitor MDL-2170 Family 17 24
Cannabinoid receptor 1 Ligand N-(3,5-dimethoxyphenethyl)oleami... 5 49
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Caspase-1 Inhibitor Z-vad-cho Family 8 34
Angiopoietin-1 receptor and Cyclin-dependent kinase 1 Inhibito... 2 10
Cathepsin B and Cathepsin K Inhibitor (s)-1-benzylcyclopentyl ... 11 5
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Oxytocin receptor Ligand [mpa1, D-tyr(et)2, D-tic7]ot Family 43 26
Fatty-acid amide hydrolase 1 Inhibitor N-butylcarbamic Acid Bi... 9 31
Fatty-acid amide hydrolase 1 Inhibitor 3-(trifluoromethyl)phen... 3 0
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 10 15
Fatty-acid amide hydrolase 1 Inhibitor 8-phenyloctylcarbamic A... 12 1
Fatty-acid amide hydrolase 1 Inhibitor Adamant-1-ylcarbamic Ac... 1 0
Fatty-acid amide hydrolase 1 Inhibitor 3-(4,5-dihydrooxazol-2-... 6 11
Neprilysin and Angiotensin-converting enzyme inhibitor AGN-PC-... 3 7
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor S-[3-(4-m... 1 2
Caspase-1 inhibitor (3S)-3-[[(2S)-4-[2-carboxyethyl(2-phenoxye... 1 3
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 6 1
Growth hormone secretagogue receptor type 1 ligand tert-butyl ... 5 4
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6S... 1 0
Growth hormone secretagogue receptor type 1 ligand 2-(2-acetyl... 2 0
Pol polyprotein inhibitor MDL 74538 family 11 1
Histamine H3 receptor and Cytochrome P450 2D6 ligand ethyl 4-[... 5 5
Angiotensin-converting enzyme 2 and Neprilysin inhibitor (2S)-... 6 1
Cathepsin S and Cathepsin L1 inhibitor benzyl N-[(2S)-1-oxo-1-... 2 2
Pol polyprotein inhibitor (3S)-N-tert-butyl-2-[(2R)-2-[(3S,6S,... 3 1
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 0
N-acylethanolamine-hydrolyzing acid amidase inhibitor (4-pheny... 1 0
N-(2,2-dimethyltetrahydro-2H-pyran-4-yl)-4-(4-methoxyphenyl)te... 2 0
Putative NP ZINC04041531 Family 40 0
N'-[[4-(4-methoxyphenyl)oxan-4-yl]methyl]-N-[(1-phenylcyclopen... 1 1
Putative NP ZINC06624157 Family 3 0
Putative NP ZINC00050501 Family 6 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00324249 CHEMBL264458 Bioactive [1-(4-methoxyphenyl)-2-methylpropan-2-yl] N-[(2S)-1-oxohexan-2-yl]carbamate
CFAMM00324242 CHEMBL117303 Bioactive [1-(3-methoxyphenyl)-2-methylpropan-2-yl] N-[(2S)-1-oxohexan-2-yl]carbamate

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26222 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543