CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14985
Family Name Dihydrofolate reductase type 1 and Dihydrofolate reductase inhibitor 5-[(2,2,4-trimethyl-8-methylsulfinyl-1H-quinolin-6-yl)methyl]pyrimidine-2,4-diamine family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00431549 Functional Category Bioactive
Superfamily Insulin receptor and ALK tyrosine kinase receptor Binder Superfamily
Class Class 1334

Cousin Family NamesSeedsMembers
Transient receptor potential cation channel subfamily V member... 15 457
Reverse transcriptase Inhibitor Dapivirine Family 5 72
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Corticotropin-releasing factor receptor 1 Ligand CP-154526 Family 9 29
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
Macrophage migration inhibitory factor Inhibitor 4-iodo-6-phen... 5 4
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... 6 16
Dihydrofolate reductase inhibitor AC1LAKWV family 2 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 3 0
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
Dihydrofolate reductase inhibitor 5-[(4-amino-3,5-dibromopheny... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00431549 CHEMBL292827 Bioactive 5-[(2,2,4-trimethyl-8-methylsulfinyl-1H-quinolin-6-yl)methyl]pyrimidine-2,4-diamine
CFAMM00431548 CHEMBL300545 Bioactive 5-[(2,2,4-trimethyl-8-methylsulfanyl-1H-quinolin-6-yl)methyl]pyrimidine-2,4-diamine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26816 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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