CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14990
Family Name Tyrosine-protein kinase Yes and Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN6617365 family
No. of Seeds 7 No. of Other Members 18
Family Centroid CFAMM00318879 Functional Category Bioactive
Superfamily Tyrosine-protein kinase Yes and Proto-oncogene tyrosine-protein kinase Src Binder Superfamily
Class Class 1340

Cousin Family NamesSeedsMembers
Receptor-type tyrosine-protein kinase FLT3 inhibitor indoline ... 4 151
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Receptor-type tyrosine-protein kinase FLT3 Inhibitor SU5614 Fa... 4 36
Fibroblast growth factor receptor 1 and Aurora kinase B Inhibi... 4 51
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Growth hormone receptor Ligand EP-51216 Family 34 390
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
Lethal factor Inhibitor GM6001 Family 50 435
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
5-hydroxytryptamine receptor 6 Ligand 4-(1h-indol-1-ylsulfonyl... 7 79
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Mineralocorticoid receptor and Androgen receptor Ligand WAY-25... 10 26
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 3-phen... 10 27
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... 1 11
Vascular endothelial growth factor receptor 2 and Receptor-typ... 7 4
Aurora kinase A and Aurora kinase B inhibitor SureCN3802769 fa... 2 20
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 4 21
Survival motor neuron protein and Menin inhibitor CHEMBL130937... 1 7
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 36
Prelamin-A/C and Pyruvate kinase PKM inhibitor CHEMBL1481187 f... 1 7
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 5 8
Neuropeptide Y receptor type 5 ligand 2-indol-1-yl-N-[4-[(prop... 7 6
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547533 f... 3 2
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 11 4
Disintegrin and metalloproteinase domain-containing protein 17... 7 9
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 4 1
Gonadotropin-releasing hormone receptor ligand SureCN7899418 f... 12 4
Leucine-rich repeat serine/threonine-protein kinase 2 and Vasc... 3 3
Leucine-rich repeat serine/threonine-protein kinase 2 and Plat... 1 0
Hepatocyte growth factor receptor and Protein-tyrosine kinase ... 2 15
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 2 3
Tyrosine-protein kinase Yes and Proto-oncogene tyrosine-protei... 1 0
Caspase-3 inhibitor pyrrolo[3,4-c]quinoline 8f family 1 16
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 2 0
5-hydroxytryptamine receptor 7 ligand AGN-PC-00PFK0 family 1 0
Caspase-3 inhibitor 2-[8-morpholin-4-ylsulfonyl-1,3-dioxo-4-[(... 2 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00431602 CHEMBL292930 Bioactive SureCN6615904
CFAMM00431595 CHEMBL55496 Bioactive SureCN6617281

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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