CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM15005
Family Name Gastrin/cholecystokinin type B receptor and Cholecystokinin receptor type A ligand 3-[[(3R,5R)-1-[2-(tert-butylamino)-2-oxoethyl]-8-methyl-2-oxo-5-phenyl-4,5-dihydro-3H-1-benzazepin-3-yl]carbamoylamino]-N-methylsulfonylbenzamide family
No. of Seeds 7 No. of Other Members 12
Family Centroid CFAMM00263117 Functional Category Bioactive
Superfamily Cholecystokinin receptor type A and Gastrin/cholecystokinin type B receptor Binder Superfamily 3
Class Class 1365

Cousin Family NamesSeedsMembers
Motilin receptor Ligand GSK962040 Family 30 457
Histone deacetylase 1 Inhibitor AN-9 Family 31 282
Intedanib family 7 54
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Vasopressin V2 receptor Ligand FR161282 Family 17 83
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
Integrin beta-3 Inhibitor SB-208651 Family 9 28
Cholecystokinin receptor type A Ligand L-708474 Family 14 82
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Cannabinoid receptor 1 Ligand 1,3,5-triphenylimidazolidine-2,4... 2 17
C-C chemokine receptor type 8 Ligand N-(4-phenylsulfamoyl-naph... 4 62
Aurora kinase B Inhibitor Hesperadin Family 1 1
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 3 26
Beta-secretase 1 and Cathepsin D Inhibitor GRL-7234 Family 17 148
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Beta-secretase 1 Inhibitor GSK-188909 Family 16 11
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 12 4
5-hydroxytryptamine receptor 2A Ligand N-(1-(4-nitrobenzyl)pip... 4 6
Vasopressin V1a receptor ligand AGN-PC-074VJP family 3 1
Substance-P receptor ligand (2S)-2-N-[(2S)-1-[benzyl(methyl)am... 2 2
Substance-P receptor ligand (2S)-2-N-[(2S)-1-[benzyl(methyl)am... 6 3
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 7 5
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 15 12
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 11 8
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 6 5
Cellular tumor antigen p53 inhibitor CHEMBL1554992 family 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 6
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075BLN ... 2 1
B1 bradykinin receptor ligand SureCN1712821 family 5 3
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 3 5
Delta-type opioid receptor and Potassium voltage-gated channel... 3 2
Baculoviral IAP repeat-containing protein 2 and E3 ubiquitin-p... 2 1
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 5 19
Nociceptin receptor ligand 2-[3-[1-[(1R)-1,2-dihydroacenaphthy... 2 0
Microsomal triglyceride transfer protein large subunit inhibit... 8 1
Substance-P receptor and Substance-K receptor ligand AGN-PC-07... 5 2
Inosine-5'-monophosphate dehydrogenase 2 inhibitor SureCN32339... 2 2
P2X purinoceptor 7 inhibitor 2-[3-fluoro-4-(trifluoromethyl)ph... 3 0
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 5 1
Growth hormone secretagogue receptor type 1 ligand 2-amino-2-m... 4 2
Substance-P receptor ligand N-[[3,5-bis(trifluoromethyl)phenyl... 1 0
Growth hormone secretagogue receptor type 1 ligand SureCN77944... 1 2
Gastrin/cholecystokinin type B receptor ligand AGN-PC-01ZDS6 f... 6 0
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 11 4
Prostaglandin E2 receptor EP1 subtype and Prostaglandin D2 rec... 1 4
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 2 5
C-C chemokine receptor type 8 ligand 3-pyrrolidin-1-ylpropyl 4... 2 0
Histone deacetylase 6 and Histone deacetylase 2 inhibitor 4-[[... 2 1
B1 bradykinin receptor ligand AGN-PC-04TG1P family 4 1
Bifunctional epoxide hydrolase 2 inhibitor N-(3-carbamoyl-4-pi... 1 0
Protein farnesyltransferase subunit beta and Protein farnesylt... 4 13
Multidrug resistance protein 1 inhibitor AGN-PC-07R6HU family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00431677 CHEMBL60754 Bioactive N-(benzenesulfonyl)-3-[[(3R,5R)-1-[2-(tert-butylamino)-2-oxoethyl]-8-methyl-2-oxo-5-phenyl-4,5-dihydro-3H-1-benzazepin-3-yl]carbamoylamino]benzamide
CFAMM00431676 CHEMBL58154 Bioactive 3-[[(3R,5R)-1-[2-(tert-butylamino)-2-oxoethyl]-8-methyl-2-oxo-5-phenyl-4,5-dihydro-3H-1-benzazepin-3-yl]carbamoylamino]-N-(2-methylphenyl)sulfonylbenzamide
CFAMM00431669 CHEMBL293490 Bioactive 3-[[(3R,5R)-1-[2-(tert-butylamino)-2-oxoethyl]-8-methyl-2-oxo-5-phenyl-4,5-dihydro-3H-1-benzazepin-3-yl]carbamoylamino]-N-ethylsulfonylbenzamide
CFAMM00431673 CHEMBL408392 Bioactive N-benzylsulfonyl-3-[[(3R,5R)-1-[2-(tert-butylamino)-2-oxoethyl]-8-methyl-2-oxo-5-phenyl-4,5-dihydro-3H-1-benzazepin-3-yl]carbamoylamino]benzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27255 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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