CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1501
Family Name Receptor-type tyrosine-protein kinase FLT3 and Vascular endothelial growth factor receptor 2 ligand 2-[5-[(Z)-[6-[(4-methoxyphenyl)carbamoylamino]-2-oxo-1H-indol-3-ylidene]methyl]-2,4-dimethyl-1H-pyrrol-3-yl]acetic acid family
No. of Seeds 4 No. of Other Members 4
Family Centroid CFAMM00324218 Functional Category Bioactive
Superfamily Receptor-type tyrosine-protein kinase FLT3 and Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Binder Superfamily
Class Class 3172

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Cyclooxygenase Inhibitor Indomethacin Family 6 271
Fibroblast growth factor receptor 1 and Aurora kinase B Inhibi... 4 51
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 4 42
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Alpha-1A adrenergic receptor Ligand A-131701 Family 16 17
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(furan-3-... 3 44
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Tyrosine-protein kinase SYK and Low affinity immunoglobulin ep... 1 0
Disintegrin and metalloproteinase domain-containing protein 17... 14 9
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 14
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Disintegrin and metalloproteinase domain-containing protein 17... 2 8
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Receptor-type tyrosine-protein kinase FLT3 and Vascular endoth... 3 4
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 3 5
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
Disintegrin and metalloproteinase domain-containing protein 17... 4 1
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
NS5B protein inhibitor AGN-PC-00A17Z family 1 23
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 19 10
MAP kinase-activated protein kinase 2 inhibitor N-[4-(4-oxospi... 3 0
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... 1 3
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
Leucine-rich repeat serine/threonine-protein kinase 2 and Vasc... 1 1
Serine/threonine-protein kinase PLK4 inhibitor (3E)-5-methoxy-... 4 0
Bifunctional epoxide hydrolase 2 inhibitor 8-(quinoline-5-carb... 1 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 1 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 1
Cyclin-dependent kinase 2 and Vascular endothelial growth fact... 1 1
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Interstitial collagenase and Matrilysin inhibitor (3S,6R,7S)-N... 2 4
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 9
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL4... 6 2
Signal transducer and activator of transcription 1-alpha/beta ... 1 36
Aurora kinase A inhibitor SureCN3802792 family 2 3
Platelet-derived growth factor receptor beta and Vascular endo... 1 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00324265 CHEMBL1173411 Bioactive 5-[(Z)-[6-[(4-methoxyphenyl)carbamoylamino]-2-oxo-1H-indol-3-ylidene]methyl]-4-methyl-1H-pyrrole-3-carboxylic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

23964 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543