CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM15020
Family Name Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-PC-073TYK family
No. of Seeds 4 No. of Other Members 20
Family Centroid CFAMM00431781 Functional Category Bioactive with Natural Product
Superfamily Histamine H3 receptor and D(3) dopamine receptor Binder Superfamily
Class Class 2433

Cousin Family NamesSeedsMembers
Cysteinyl leukotriene receptor 1 Ligand Zafirlukast Family 48 78
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Sodium channel protein type 5 subunit alpha Ligand Dibucaine F... 2 136
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Cyclooxygenase Inhibitor Indomethacin Family 6 271
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
Coagulation factor X Inhibitor Apixaban Family 34 52
Vascular endothelial growth factor receptor 2 Ligand E 7080 Fa... 7 17
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 4 42
Indeglitazar family 3 39
Nicotinic acetylcholine receptor alpha2 / alpha3 Ligand Ibogai... 3 21
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 2-benzyl-6-... 9 80
Adenosine receptor A1 and Adenosine receptor A3 Ligand 4-metho... 1 16
Integrin beta-3 Inhibitor L-756568 Family 8 59
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Oestrogen receptor and Estrogen receptor beta Ligand 4-(3-phen... 5 14
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(furan-3-... 3 44
Platelet-derived growth factor receptor alpha and Platelet-der... 4 54
Platelet-derived growth factor receptor alpha and Platelet-der... 2 13
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Serine/threonine-protein kinase Chk1 and Wee1-like protein kin... 2 101
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-366... 5 75
Cyclin-dependent kinase 2 and G1/S-specific cyclin-E1 Inhibito... 5 1
5-hydroxytryptamine receptor 2A and Alpha-2A adrenergic recept... 4 29
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 24 64
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 31
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 6 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 7 44
Tyrosine-protein kinase SYK and Low affinity immunoglobulin ep... 1 0
Disintegrin and metalloproteinase domain-containing protein 17... 14 9
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 2 30
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 14
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Disintegrin and metalloproteinase domain-containing protein 17... 2 8
Cathepsin K and Cathepsin S inhibitor dipeptidyl nitrile, 16f ... 3 18
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 1 18
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 11 391
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 10 4
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 3 28
Vascular endothelial growth factor receptor 2 ligand indolyl q... 4 3
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 3 5
Receptor-type tyrosine-protein kinase FLT3 and Vascular endoth... 4 4
Vascular endothelial growth factor receptor 2 ligand indolyl q... 2 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 8 32
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 8 21
Somatostatin receptor type 5 and Somatostatin receptor type 1 ... 2 8
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Renin inhibitor SureCN1144364 family 3 15
Vascular endothelial growth factor receptor 2 and Aurora kinas... 3 3
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 4 14
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
Histamine H3 receptor ligand (4S)-7-bromo-4-methyl-8-(1-propan... 2 0
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 2 21
Renin inhibitor AGN-PC-09M9MJ family 2 23
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 5
Sodium channel protein type 10 subunit alpha and Sodium channe... 3 22
Disintegrin and metalloproteinase domain-containing protein 17... 4 1
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
Cellular tumor antigen p53 inhibitor CHEMBL1395699 family 1 30
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... 2 2
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
D(3) dopamine receptor ligand N-[4-[4-(2,3-dichlorophenyl)pipe... 3 15
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 21
Acetylcholinesterase inhibitor CHEMBL1651140 family 4 4
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 2 3
Cannabinoid receptor 1 ligand 5-cyano-N-(3-hydroxy-2,2-dimethy... 17 4
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 0
Coagulation factor X and Trypsin-1 inhibitor AGN-PC-0759OR family 4 7
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 5
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 19
Histone deacetylase 3 and Histone deacetylase 9 inhibitor (3S,... 1 16
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801290 ... 3 0
Histone deacetylase 1 and Potassium voltage-gated channel subf... 1 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 2
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 2
NS5B protein inhibitor AC1O5AET family 3 1
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 19 10
Glucagon receptor ligand 3-[[4-[(2S)-2-[5-(trifluoromethoxy)-1... 1 2
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 13 1
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 14 2
Serine/threonine-protein kinase pim-2 and cGMP-dependent prote... 8 1
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Vascular endothelial growth factor receptor 2 and Vascular end... 2 52
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... 11 12
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 3 2
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 159
Cathepsin K inhibitor (1R,2R)-N-(1-cyanocyclopropyl)-2-(6-meth... 3 0
Mu-type opioid receptor and Mu-type opioid receptor ligand (3S... 6 2
Fatty-acid amide hydrolase 1 inhibitor [3-(3-carbamoylpyrrol-1... 4 6
Substance-P receptor ligand AGN-PC-01VLKE family 9 11
Acetylcholinesterase and Cholinesterase inhibitor N-[5-[(6-chl... 4 2
Transient receptor potential cation channel subfamily V member... 1 5
3-oxo-5-alpha-steroid 4-dehydrogenase 2 inhibitor 4-(benzyloxy... 1 10
Peroxisome proliferator-activated receptor delta and Peroxisom... 7 5
Beta-2 adrenergic receptor ligand SureCN5346426 family 8 0
Beta-2 adrenergic receptor ligand SureCN4598646 family 7 7
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... 1 3
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
Leucine-rich repeat serine/threonine-protein kinase 2 and Vasc... 1 1
Serine/threonine-protein kinase PLK4 inhibitor (3E)-5-methoxy-... 4 0
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 1 0
C-C chemokine receptor type 5 ligand N-methyl-4-[6-methyl-5-[[... 2 2
Glutamate receptor ionotropic, NMDA 2B ligand SureCN5532501 fa... 1 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 1 1
Gonadotropin-releasing hormone receptor ligand SureCN7905635 f... 2 2
Platelet-activating factor receptor ligand N,N-dimethyl-6-phen... 12 18
Neutrophil collagenase and Stromelysin-1 inhibitor (3R)-N-hydr... 2 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 0
Mu-type opioid receptor ligand MITRAGYNINE family 2 8
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 2 1
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Substance-P receptor ligand SureCN2139814 family 7 7
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 6 8
Coagulation factor X and Prothrombin inhibitor SureCN6434488 f... 3 13
Vasopressin V2 receptor and Vasopressin V1a receptor ligand Su... 2 2
Interstitial collagenase and Matrilysin inhibitor (3S,6R,7S)-N... 2 4
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 1 8
Vasopressin V2 receptor ligand SureCN4400636 family 1 0
Gonadotropin-releasing hormone receptor ligand 2-[2-(4-methoxy... 1 1
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-(3-me... 2 10
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 9
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
Histone deacetylase 1 inhibitor (7S)-N-hydroxy-7-[[2-(5-methox... 1 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL4... 6 2
5-hydroxytryptamine receptor 2B ligand SureCN1299002 family 2 8
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 0
Histamine H3 receptor ligand SureCN1397929 family 1 1
5-hydroxytryptamine receptor 4 ligand 4-amino-5-chloro-N-[1-[8... 2 2
P2Y purinoceptor 12 inhibitor (4S)-4-[[4-[(1-acetylpiperidin-4... 58 15
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 3
Mitogen-activated protein kinase 14 inhibitor SureCN4508019 fa... 1 0
Growth factor receptor-bound protein 2 ligand [4-[(2S)-2-aceta... 2 1
Signal transducer and activator of transcription 1-alpha/beta ... 1 36
Gamma-aminobutyric acid receptor subunit pi and Gamma-aminobut... 2 10
Potassium voltage-gated channel subfamily A member 5 ligand AG... 1 0
Histone deacetylase 1 inhibitor (2S)-2-[[2-(5-methoxy-2-methyl... 2 2
Aurora kinase A inhibitor SureCN3802792 family 2 3
Platelet-derived growth factor receptor beta and Vascular endo... 1 3
Neurotensin receptor type 1 and Neurotensin receptor type 2 li... 1 1
Indoles Metabolite Mukeic acid Family 1 1
Indoles Metabolite Koeniginequinone B Family 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00431775 CHEMBL56214 Bioactive AGN-PC-073TYI
CFAMM00431766 CHEMBL293812 Bioactive AGN-PC-073TYJ
CFAMM00431772 CHEMBL294194 Bioactive AGN-PC-073TW7
CFAMM00431781 CHEMBL57792 Bioactive AGN-PC-073TYK

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27523 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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