CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM15043
Family Name 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine receptor 1B ligand AGN-PC-074AA3 family
No. of Seeds 2 No. of Other Members 2
Family Centroid CFAMM00431907 Functional Category Bioactive
Superfamily D(2) dopamine receptor and D(1A) dopamine receptor ligand ergoline derivative Pergolide Superfamily
Class Class 64

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B ligand triptan Almotriptan Family 8 438
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... 26 1171
Solute carrier family 12 member 1 Inhibitor Torasemide Family 13 75
Transient receptor potential cation channel subfamily V member... 15 158
Thromboxane A2 receptor Ligand Ramatroban Family 13 49
5-hydroxytryptamine receptor 6 Ligand SB-742457 Family 9 66
Growth hormone receptor Ligand EP-51216 Family 34 390
D(3) dopamine receptor Ligand SB-277011 Family 13 178
E7820 family 9 56
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
Lethal factor Inhibitor GM6001 Family 50 435
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
5-hydroxytryptamine receptor 2B Ligand Sb 206553 Family 14 21
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
5-hydroxytryptamine receptor 6 Ligand E-6837 Family 22 44
5-hydroxytryptamine receptor 6 Ligand 4-(4,6-dinitro-1h-indol-... 4 19
5-hydroxytryptamine receptor 6 Ligand 4-(1h-indol-1-ylsulfonyl... 7 79
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 14 19
NF-kappa-B Inhibitor 9-chloro-5h-6-thia-4,5-diaza-chrysene 6,6... 3 27
Carbonic anhydrase 2 and Carbonic anhydrase 9 Inhibitor Quinol... 4 13
5-hydroxytryptamine receptor 6 Ligand 6-tosyl-1,2,3,4,5,6-hexa... 4 22
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Histone deacetylase Inhibitor ST-5732 Family 8 6
Motilin receptor and Cytochrome P450 2D6 ligand 7-[[6-(4-chlor... 2 1
Protein kinase C theta type and Protein kinase C delta type in... 7 17
Dipeptidyl peptidase 1 inhibitor (2S)-2-amino-N-[(1S)-1-cyano-... 2 14
5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... 1 11
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 27
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 11 20
Cannabinoid receptor 2 ligand AGN-PC-09M5PW family 12 2
Cannabinoid receptor 2 ligand 1,1,1-trifluoro-N-[(2S)-6-(1-pyr... 2 1
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 8
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 8
Survival motor neuron protein and Menin inhibitor CHEMBL151109... 1 11
Platelet-activating factor receptor ligand YM-461 family 1 11
Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3
Substance-K receptor and Cytochrome P450 2D6 ligand 158848-32-... 4 4
Mineralocorticoid receptor and Glucocorticoid receptor ligand ... 5 0
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 13 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 5
5-hydroxytryptamine receptor 6 ligand SureCN3411879 family 10 3
5-hydroxytryptamine receptor 6 and Muscarinic acetylcholine re... 7 3
Renin and Potassium voltage-gated channel subfamily H member 2... 9 2
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 12 0
CGMP-dependent protein kinase inhibitor AGN-PC-075XII family 25 7
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 0
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[3-[(4-fluo... 3 2
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
Neuropeptide Y receptor type 5 ligand 2-indol-1-yl-N-[4-[(prop... 7 6
Substance-P receptor ligand [3,5-bis(trifluoromethyl)phenyl]-[... 17 1
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-(4-quinolin-4-ylpi... 5 8
5-hydroxytryptamine receptor 6 ligand 9-(benzenesulfonyl)-N,N-... 7 1
Glutamate receptor ionotropic, NMDA 2B ligand N-[3-[2-(4-benzy... 2 0
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 6 8
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 4
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 5 2
C-C chemokine receptor type 2 ligand 2-[4-(5-amino-1H-indol-3-... 3 2
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
C-C chemokine receptor type 2 ligand SureCN5947024 family 11 0
CGMP-dependent protein kinase inhibitor 1-[4-acetyl-3-[[4-[5-(... 2 0
Platelet-activating factor receptor ligand (1-ethylindol-3-yl)... 17 13
Neutrophil collagenase and Interstitial collagenase inhibitor ... 1 0
5-hydroxytryptamine receptor 7 ligand 6-[(2R)-2-[2-(4-methylpi... 1 0
Gonadotropin-releasing hormone receptor ligand 1-[2-(3,5-dimet... 2 0
CGMP-dependent protein kinase inhibitor 2-[[4-[5-(4-fluorophen... 1 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 5 0
Cannabinoid receptor 2 ligand 1-(benzenesulfonyl)-N-quinolin-3... 2 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 4
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(4-py... 9 0
Prostaglandin G/H synthase 2 inhibitor SureCN6345015 family 6 1
5-hydroxytryptamine receptor 6 ligand 2-[[(1Z)-1-[5-(benzenesu... 1 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 0
5-hydroxytryptamine receptor 6 ligand 4-bromo-N-[3-[[(2S)-1-me... 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00431907 CHEMBL294425 Bioactive AGN-PC-074AA3
CFAMM00431910 CHEMBL299917 Bioactive AGN-PC-073U6H

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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