CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1509
Family Name Epidermal growth factor receptor ligand N-[4-(3-chloro-4-fluoroanilino)-7-ethoxyquinazolin-6-yl]prop-2-enamide family
No. of Seeds 6 No. of Other Members 47
Family Centroid CFAMM00324402 Functional Category Bioactive
Superfamily Epidermal growth factor receptor and Dihydrofolate reductase Binder Superfamily
Class Class 831

Cousin Family NamesSeedsMembers
Alpha-1D adrenergic receptor Ligand Terazosin Family 28 638
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Epidermal growth factor receptor and Receptor tyrosine-protein... 16 89
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-... 25 40
Receptor tyrosine-protein kinase erbB-2 Inhibitor TAK-285 Family 16 124
AP26113 family 16 90
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Melanin-concentrating hormone receptor 1 Ligand Gnf-pf-2322 Fa... 3 95
Melanin-concentrating hormone receptor 1 Ligand ADS-102891 Family 6 51
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Sodium channel protein type 5 subunit alpha Ligand Enecadin Fa... 1 11
Proto-oncogene tyrosine-protein kinase Src inhibitor N-(2,4-di... 3 0
Tyrosine-protein kinase Lck inhibitor 4-N-(2-chloro-6-methylph... 8 45
Tyrosine-protein kinase Lck inhibitor AGN-PC-073GX8 family 12 1
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Vascular endothelial growth factor receptor 2 and Vascular end... 3 3
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 1 1
Serine/threonine-protein kinase Chk2 and Serine/threonine-prot... 1 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 6 9
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 9 10
Insulin receptor and Insulin-like growth factor 1 receptor lig... 17 7
Insulin-like growth factor 1 receptor and Potassium voltage-ga... 2 2
Fatty-acid amide hydrolase 1 inhibitor (1R)-2-[[6-(3-chloro-4-... 1 4
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
Insulin-like growth factor 1 receptor ligand GSK1220512A family 20 15
Insulin-like growth factor 1 receptor ligand 4-(2,3-dihydroind... 1 0
Proto-oncogene tyrosine-protein kinase Src and Vascular endoth... 7 3
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 4 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 8 1
Aurora kinase A inhibitor AGN-PC-0760BB family 1 1
Epidermal growth factor receptor ligand SureCN4454332 family 18 5
Tyrosine-protein kinase Lck inhibitor AGN-PC-0762WF family 2 0
Aurora kinase A inhibitor SureCN4289024 family 1 0
TRAF2 and NCK-interacting protein kinase and Serine/threonine-... 2 2
TRAF2 and NCK-interacting protein kinase inhibitor 4-methoxy-3... 4 1
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Renin and Cytochrome P450 3A4 inhibitor AGN-PC-046RG9 family 8 28
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 9 2
Transient receptor potential cation channel subfamily V member... 2 0
Epidermal growth factor receptor ligand AGN-PC-078X8C family 10 8
Epidermal growth factor receptor ligand SureCN2989664 family 5 2
Epidermal growth factor receptor and Receptor tyrosine-protein... 8 0
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 1 0
Macrophage colony-stimulating factor 1 receptor ligand 4-(2,3-... 12 7
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 10 4
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 6 1
Epidermal growth factor receptor and Receptor tyrosine-protein... 1 0
Epidermal growth factor receptor ligand 4-Anilinoquinazoline d... 2 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00324402 CHEMBL2031302 Bioactive N-[4-(3-chloro-4-fluoroanilino)-7-ethoxyquinazolin-6-yl]prop-2-enamide
CFAMM00324369 CHEMBL489306 Bioactive AGN-PC-078XAM
CFAMM00324382 CHEMBL569880 Bioactive SureCN4846380
CFAMM00324395 CHEMBL32079 Bioactive AGN-PC-073HW8
CFAMM00324366 CHEMBL597773 Bioactive AGN-PC-04UE95
CFAMM00324392 CHEMBL522928 Bioactive AGN-PC-078XAN

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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