CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM15092
Family Name Substance-P receptor ligand N-[(2R)-1-[acetyl-[(2-chlorophenyl)methyl]amino]-3-(1H-indol-3-yl)propan-2-yl]-2-(4-imidazol-1-ylphenoxy)acetamide family
No. of Seeds 2 No. of Other Members 2
Family Centroid CFAMM00432294 Functional Category Bioactive with Natural Product
Superfamily Substance-P receptor and Vasopressin V2 receptor Binder Superfamily 4
Class Class 2014

Cousin Family NamesSeedsMembers
Leutinizing-hormone-releasing hormone inhibitor peptide Leupro... 43 911
Epidermal Growth Factor family 111 209
Melatonin receptor type 1A Ligand Melatonin Family 20 988
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 11 49
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
Eluxadoline family 4 85
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Renin Inhibitor Enalkiren Family 56 44
Cyclin-dependent kinase 1 and Cyclin-dependent kinase 2 Inhibi... 1 8
D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1... 17 100
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
D(2) dopamine receptor Ligand SLV-314 Family 19 69
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Melanin-concentrating hormone receptor 1 Ligand ADS-103214 Family 3 4
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
Type-1 angiotensin II receptor Ligand [sar1,tdf3]angii Family 135 2
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Potassium voltage-gated channel subfamily H member 2 Ligand (1... 64 70
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 17 69
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN97387... 4 1
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 7 16
Protein farnesyltransferase subunit beta and Protein farnesylt... 3 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 7 5
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Su... 2 16
Aurora kinase A inhibitor SureCN761545 family 2 2
Aurora kinase A inhibitor SureCN761045 family 2 0
5-hydroxytryptamine receptor 2A and Alpha-1A adrenergic recept... 4 1
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL2... 3 8
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
D(3) dopamine receptor and D(2) dopamine receptor ligand 2-[4-... 2 3
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Platelet-activating factor receptor ligand SureCN7497229 family 4 2
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 2 11
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 14 2
Serine/threonine-protein kinase B-raf and RAF proto-oncogene s... 1 0
Histamine H3 receptor ligand AGN-PC-075YXY family 1 4
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Platelet-derived growth factor receptor alpha and Vascular end... 3 1
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 3 1
Growth hormone secretagogue receptor type 1 ligand SureCN36800... 14 42
Growth hormone secretagogue receptor type 1 ligand SureCN36380... 6 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 3 5
Growth hormone secretagogue receptor type 1 ligand N-[(1R)-2-(... 3 2
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 5
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[1-(4-ethoxyp... 5 9
Pol polyprotein and Protease inhibitor 161186-51-2 family 5 0
Adenosine deaminase inhibitor 1-[(3R,4S)-1-[2-(4-chlorophenyl)... 3 6
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 8 6
Substance-P receptor ligand N-[(2R)-1-[acetyl-[(2-methoxypheny... 1 0
Substance-P receptor ligand AGN-PC-00FIT5 family 3 11
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
Histone deacetylase 1 inhibitor (7S)-N-hydroxy-7-[[2-(5-methox... 1 2
Rho-associated protein kinase 2 inhibitor SureCN1519463 family 5 1
Sphingosine 1-phosphate receptor 1 ligand (2S)-2-[[2-(1H-imida... 4 7
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN8919280 f... 23 18
Acyl-CoA:cholesterol acyltransferase inhibitor AGN-PC-00FHC0 f... 2 0
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN8919926 f... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00432294 CHEMBL296013 Bioactive N-[(2R)-1-[acetyl-[(2-chlorophenyl)methyl]amino]-3-(1H-indol-3-yl)propan-2-yl]-2-(4-imidazol-1-ylphenoxy)acetamide
CFAMM00432293 CHEMBL47070 Bioactive N-[(2R)-1-[acetyl-[(2-methoxyphenyl)methyl]amino]-3-(1H-indol-3-yl)propan-2-yl]-2-(4-imidazol-1-ylphenoxy)acetamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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