CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1511
Family Name Dihydrofolate reductase inhibitor 5-[(3,5-dimethoxy-4-methylphenyl)methyl]-4,5-dihydropyrimidine-2,6-diamine family
No. of Seeds 4 No. of Other Members 16
Family Centroid CFAMM00324428 Functional Category Bioactive
Superfamily Dihydrofolate reductase Binder Superfamily
Class Class 3386

Cousin Family NamesSeedsMembers
Glutamate receptor ionotropic, NMDA 2A and Glutamate receptor ... 3 10
Dihydrofolate reductase inhibitor 4-[(2,6-diamino-4,5-dihydrop... 2 7
Dihydrofolate reductase inhibitor 5-[(3,5-dimethoxy-4-phenylme... 2 8


External ID

Functional Category

Molecule Name

CFAMM00324437 CHEMBL118262 Bioactive 5-[(3,5-dimethoxyphenyl)methyl]-4,5-dihydropyrimidine-2,6-diamine
CFAMM00324442 CHEMBL117390 Bioactive 5-[[3,5-dimethoxy-4-(2-methoxyethyl)phenyl]methyl]-4,5-dihydropyrimidine-2,6-diamine
CFAMM00324428 CHEMBL119640 Bioactive 5-[(3,5-dimethoxy-4-methylphenyl)methyl]-4,5-dihydropyrimidine-2,6-diamine
CFAMM00324427 CHEMBL332543 Bioactive 5-[(4-bromo-3,5-dimethoxyphenyl)methyl]-4,5-dihydropyrimidine-2,6-diamine

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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