CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM15121
Family Name Gonadotropin-releasing hormone receptor ligand 2-tert-butyl-8-[(2-fluorophenyl)methyl]-6-(3-methoxyphenyl)-7-methyl-3-[[methyl(2-pyridin-2-ylethyl)amino]methyl]imidazo[1,2-a]pyrimidin-5-one family
No. of Seeds 6 No. of Other Members 23
Family Centroid CFAMM00432401 Functional Category Bioactive
Superfamily P2X purinoceptor 7 Inhibitor A-740003 Superfamily
Class Class 2472

Cousin Family NamesSeedsMembers
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Gonadotropin-releasing hormone receptor ligand 1-[(2,6-difluor... 6 31
Gonadotropin-releasing hormone receptor ligand ethyl 8-fluoro-... 1 19
Casein kinase I isoform delta and Mitogen-activated protein ki... 3 18
Gonadotropin-releasing hormone receptor ligand AGN-PC-074DKH f... 15 46
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Serine/threonine-protein kinase PLK1 inhibitor AGN-PC-0A9RFQ f... 2 1
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[2-(die... 12 2
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[1-(4-ethoxyp... 5 9
Histamine H1 receptor and Substance-P receptor ligand SureCN13... 24 48
Mitogen-activated protein kinase 14 inhibitor SureCN4913214 fa... 1 2
Cannabinoid receptor 2 ligand AGN-PC-03LKW5 family 24 5
Rho-associated protein kinase 2 inhibitor AGN-PC-078WHL family 3 1
Translocator protein inhibitor AGN-PC-04X3HY family 10 1
Acyl-CoA desaturase inhibitor SureCN1182719 family 1 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M5I2 fa... 1 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00432399 CHEMBL52506 Bioactive 2-tert-butyl-3-[[ethyl(2-pyridin-2-ylethyl)amino]methyl]-8-[(2-fluorophenyl)methyl]-6-(3-methoxyphenyl)-7-methylimidazo[1,2-a]pyrimidin-5-one
CFAMM00432418 CHEMBL298982 Bioactive methyl 2-[8-[(2-fluorophenyl)methyl]-6-(3-methoxyphenyl)-7-methyl-3-[[methyl(2-pyridin-2-ylethyl)amino]methyl]-5-oxoimidazo[1,2-a]pyrimidin-2-yl]-2-methylpropanoate
CFAMM00432424 CHEMBL299348 Bioactive methyl 2-[8-[(2-fluorophenyl)methyl]-6-(3-methoxyphenyl)-7-methyl-3-[[methyl(pyridin-2-ylmethyl)amino]methyl]-5-oxoimidazo[1,2-a]pyrimidin-2-yl]-2-methylpropanoate
CFAMM00432417 CHEMBL300079 Bioactive 8-[(2-fluorophenyl)methyl]-2-(1-hydroxy-2-methylpropan-2-yl)-6-(3-methoxyphenyl)-7-methyl-3-[[methyl(pyridin-2-ylmethyl)amino]methyl]imidazo[1,2-a]pyrimidin-5-one
CFAMM00432422 CHEMBL297491 Bioactive 8-[(2-fluorophenyl)methyl]-6-(3-methoxyphenyl)-2-(4-methoxyphenyl)-7-methyl-3-[[methyl(2-pyridin-2-ylethyl)amino]methyl]imidazo[1,2-a]pyrimidin-5-one
CFAMM00432401 CHEMBL50546 Bioactive 2-tert-butyl-8-[(2-fluorophenyl)methyl]-6-(3-methoxyphenyl)-7-methyl-3-[[methyl(2-pyridin-2-ylethyl)amino]methyl]imidazo[1,2-a]pyrimidin-5-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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