CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM15125
Family Name Type-1 angiotensin II receptor and Type-2 angiotensin II receptor ligand (2E)-2-[2-methyl-3-[[4-[2-(2H-tetrazol-5-yl)pyrrol-1-yl]phenyl]methyl]-5,6,7,8-tetrahydrocyclohepta[d]imidazol-4-ylidene]acetic acid family
No. of Seeds 9 No. of Other Members 2
Family Centroid CFAMM00432442 Functional Category Bioactive
Superfamily Type-1 angiotensin II receptor and Type-2 angiotensin II receptor Binder Superfamily 12
Class Class 3528

Cousin Family NamesSeedsMembers
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
Type-1 angiotensin II receptor Ligand Losartan Family 3 90
Type-1 angiotensin II receptor Ligand Telmisartan Family 4 181
Type-1 angiotensin II receptor Ligand Olmesartan Family 13 65
Type-1 angiotensin II receptor Ligand Forasartan Family 3 253
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
PF-4217903 family 14 65
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Type-2 angiotensin II receptor Ligand L-158809 Family 22 136
Type-2 angiotensin II receptor Ligand SC-50560 Family 3 84
Type-2 angiotensin II receptor Ligand SC-55634 Family 8 5
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 14 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 3 12
Platelet-activating factor receptor ligand AGN-PC-0750SP family 4 0
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 16 30
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 16 34
Histamine H3 receptor ligand SureCN4025673 family 4 2
Type-1 angiotensin II receptor ligand SureCN9527437 family 2 34
C-X-C chemokine receptor type 4 and Envelope glycoprotein gp16... 2 2
DNA-dependent protein kinase catalytic subunit and Tyrosine-pr... 2 10
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 4 4
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 6 27
Type-1B angiotensin II receptor ligand 2-[2-butyl-3-[[4-[2-(2H... 1 0
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 3 6
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 6 44
Type-1B angiotensin II receptor ligand SureCN683399 family 3 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 7 9
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL14574... 1 2
D(4) dopamine receptor and D(2) dopamine receptor ligand 4-met... 13 8
Nuclear receptor ROR-gamma and Mitogen-activated protein kinas... 1 10
Glycogen synthase kinase-3 beta and Dual specificity protein k... 4 5
Platelet-activating factor receptor ligand SureCN7491834 family 28 15
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 5
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 9 6
Type-1B angiotensin II receptor ligand lithium;[2-butyl-5-chlo... 1 2
Type-1 angiotensin II receptor and Peroxisome proliferator-act... 6 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 4 2
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 1 0
TGF-beta receptor type-1 and TGF-beta receptor type-2 ligand S... 2 2
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 6 5
Mitogen-activated protein kinase 14 inhibitor imidazole 81 family 2 1
Type-1 angiotensin II receptor and Type-1A angiotensin II rece... 3 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6
Type-1 angiotensin II receptor ligand 5-[2-[4-[[4-butyl-3-[[4-... 4 2
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 2 0
D(3) dopamine receptor and Muscarinic acetylcholine receptor M... 8 2
Cyclin-dependent kinase 1 and Proto-oncogene tyrosine-protein ... 5 13
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 16 7
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 3 0
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 10 0
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 35 14
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 8 2
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 2 0
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 4 1
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 2 0
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 3 4
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 5 0
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 5 0
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 3 0
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 2 0
Type-1 angiotensin II receptor ligand 2-[(2-ethyl-5,7-dimethyl... 5 3
Type-1 angiotensin II receptor ligand SureCN7390271 family 2 1
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 3 0
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 1 0
Alpha-1A adrenergic receptor and Alpha-2A adrenergic receptor ... 3 0
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 2 0
Glycogen synthase kinase-3 beta inhibitor 1-(4-amino-1,2,5-oxa... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00432436 CHEMBL43540 Bioactive (2E)-2-[2-ethyl-3-[[4-[2-(2H-tetrazol-5-yl)pyrrol-1-yl]phenyl]methyl]-5,6,7,8-tetrahydrocyclohepta[d]imidazol-4-ylidene]acetic acid
CFAMM00432442 CHEMBL297637 Bioactive (2E)-2-[2-methyl-3-[[4-[2-(2H-tetrazol-5-yl)pyrrol-1-yl]phenyl]methyl]-5,6,7,8-tetrahydrocyclohepta[d]imidazol-4-ylidene]acetic acid
CFAMM00432440 CHEMBL42984 Bioactive (2E)-2-[2-pentyl-3-[[4-[2-(2H-tetrazol-5-yl)pyrrol-1-yl]phenyl]methyl]-5,6,7,8-tetrahydrocyclohepta[d]imidazol-4-ylidene]acetic acid
CFAMM00432439 CHEMBL44295 Bioactive (2E)-2-[2-propyl-3-[[4-[2-(2H-tetrazol-5-yl)pyrrol-1-yl]phenyl]methyl]-5,6,7,8-tetrahydrocyclohepta[d]imidazol-4-ylidene]acetic acid
CFAMM00432438 CHEMBL75518 Bioactive ethyl (E)-2-methyl-3-[2-propyl-5-pyrrol-1-yl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]prop-2-enoate
CFAMM00432437 CHEMBL443000 Bioactive (2E)-2-[2-butyl-3-[[4-[2-(2H-tetrazol-5-yl)pyrrol-1-yl]phenyl]methyl]-5,6,7,8-tetrahydrocyclohepta[d]imidazol-4-ylidene]acetic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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