CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM15151
Family Name Sigma non-opioid intracellular receptor 1 and D(3) dopamine receptor ligand 4-bromo-N-[(3R)-1-cyclohexylpyrrolidin-3-yl]-1-methoxynaphthalene-2-carboxamide family
No. of Seeds 26 No. of Other Members 8
Family Centroid CFAMM00291443 Functional Category Bioactive
Superfamily D(3) dopamine receptor and Prelamin-A/C Binder Superfamily
Class Class 216

Cousin Family NamesSeedsMembers
D(2) dopamine receptor Ligand Remoxipride Family 12 84
Sodium channel protein type 5 subunit alpha Ligand Flecainide ... 2 162
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Histamine H3 receptor Ligand A-349821 Family 49 228
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
D(2) dopamine receptor Ligand Epidepride Family 31 66
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 2 0
Disintegrin and metalloproteinase domain-containing protein 17... 28 10
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 55 36
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[(3... 2 11
D(2) dopamine receptor and D(3) dopamine receptor ligand 5-bro... 3 11
D(2) dopamine receptor ligand 2-bromo-3-chloro-N-[[(2S)-1-ethy... 1 1
D(2) dopamine receptor ligand 2-chloro-3-ethyl-N-[[(2S)-1-ethy... 3 0
D(2) dopamine receptor ligand 2-bromo-N-[[(2S)-1-ethylpyrrolid... 3 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Substance-P receptor ligand AGN-PC-075NP5 family 4 8
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 2
Prelamin-A/C and Retinal dehydrogenase 1 inhibitor CHEMBL15810... 1 1
Pol polyprotein inhibitor CHEMBL305466 family 4 7
Orexin receptor type 1 and Orexin receptor type 2 ligand [(2S)... 3 1
B1 bradykinin receptor ligand 4-(5-chloro-4-oxochromen-3-yl)-N... 1 5
Growth hormone secretagogue receptor type 1 ligand 2-[(2S)-1-[... 2 0
Nociceptin receptor and Kappa-type opioid receptor ligand AGN-... 1 3
Melanocortin receptor 4 ligand 2-[2-(5-bromo-2-methoxyphenyl)e... 6 12
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 15 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 3
E3 ubiquitin-protein ligase XIAP and Cytochrome P450 3A4 inhib... 4 11
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 15
D(3) dopamine receptor and D(4) dopamine receptor ligand SureC... 3 19
Melanin-concentrating hormone receptor 1 ligand N-methyl-N-[(3... 2 2
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 0
Muscarinic acetylcholine receptor M3 ligand N-[[3-[3-[(3-methy... 5 2
C-C chemokine receptor type 3 and Probable C-C chemokine recep... 5 2
C-C chemokine receptor type 3 ligand N-[(3R)-1-[(6-fluoronapht... 1 4
D(3) dopamine receptor ligand S33084 family 1 1
Sodium/hydrogen exchanger 1 inhibitor 4-(1-acetylpiperidin-4-y... 1 1
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00432575 CHEMBL51959 Bioactive SureCN8525976
CFAMM00432574 CHEMBL53401 Bioactive N-[1-(9-bicyclo[3.3.1]nonanyl)piperidin-4-yl]-4-bromo-1-methoxynaphthalene-2-carboxamide
CFAMM00432587 CHEMBL52298 Bioactive N-[(3S)-1-(2-adamantyl)pyrrolidin-3-yl]-4-bromo-1-methoxynaphthalene-2-carboxamide
CFAMM00432580 CHEMBL301929 Bioactive N-[[(2R)-1-(2-adamantyl)pyrrolidin-2-yl]methyl]-4-bromo-1-methoxynaphthalene-2-carboxamide
CFAMM00432573 CHEMBL62638 Bioactive AGN-PC-074CGZ
CFAMM00432572 CHEMBL54667 Bioactive 4-bromo-N-[(3S)-1-cycloheptylpyrrolidin-3-yl]-1-methoxynaphthalene-2-carboxamide
CFAMM00432578 CHEMBL51754 Bioactive N-[(3R)-1-(2-adamantyl)pyrrolidin-3-yl]-4-bromo-1-methoxynaphthalene-2-carboxamide
CFAMM00432583 CHEMBL54865 Bioactive 4-bromo-N-[(3S)-1-cyclohexylpyrrolidin-3-yl]-1-methoxynaphthalene-2-carboxamide
CFAMM00432570 CHEMBL54662 Bioactive N-[[(2S)-1-(9-bicyclo[3.3.1]nonanyl)pyrrolidin-2-yl]methyl]-4-bromo-1-methoxynaphthalene-2-carboxamide
CFAMM00432576 CHEMBL50465 Bioactive N-[(3S)-1-benzylpyrrolidin-3-yl]-4-bromo-1-methoxynaphthalene-2-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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