CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1516
Family Name Pol polyprotein inhibitor morpholinone scaffold 1 family
No. of Seeds 5 No. of Other Members 29
Family Centroid CFAMM00324481 Functional Category Bioactive
Superfamily Pol polyprotein and Collagenase 3 Binder Superfamily
Class Class 3387

Cousin Family NamesSeedsMembers
Disintegrin and metalloproteinase domain-containing protein 17... 82 411
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 6 16
Matrix metalloproteinase-9 and Collagenase 3 inhibitor 4-benzy... 10 32
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 3 13
Disintegrin and metalloproteinase domain-containing protein 17... 10 39
Cathepsin K inhibitor SureCN6578603 family 1 3
Collagenase 3 and Matrix metalloproteinase-9 inhibitor 4-acety... 9 4
Pol polyprotein inhibitor benzyl (2S)-2-[[[(2S)-3-[cyclopentyl... 2 6
Collagenase 3 and Stromelysin-1 inhibitor 1-N-benzyl-3-N-hydro... 7 15
Pol polyprotein inhibitor AC1LA9K7 family 7 23
Collagenase 3 and 72 kDa type IV collagenase inhibitor (2R,4S)... 7 1
Collagenase 3 and Stromelysin-1 inhibitor (2R,4S)-N-hydroxy-4-... 7 0
72 kDa type IV collagenase and Collagenase 3 inhibitor (2R,4S)... 3 0
Pol polyprotein inhibitor AC1NQUJL family 10 11
Macrophage metalloelastase and 72 kDa type IV collagenase inhi... 7 4
Pol polyprotein inhibitor arylsulfonamide 10c family 17 2
Disintegrin and metalloproteinase domain-containing protein 17... 25 5
Collagenase 3 and 72 kDa type IV collagenase inhibitor (2R)-2-... 2 0
Collagenase 3 and Neutrophil collagenase inhibitor (3R)-1-hydr... 1 0
Kappa-type opioid receptor and Cytochrome P450 2D6 ligand N-[(... 1 0
Pol polyprotein inhibitor N-[2-Hydroxy-2-(8-Isopropyl-6,9-Diox... 7 6
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 10 2
C-C chemokine receptor type 5 ligand phenyl N-[1-[(3S)-4-[benz... 2 5
Neutrophil collagenase and Interstitial collagenase inhibitor ... 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00324481 CHEMBL182360 Bioactive morpholinone scaffold 1
CFAMM00324510 CHEMBL386137 Bioactive N-[(2S)-3-[(2R,5S)-5-benzyl-3-oxo-2-prop-2-enylmorpholin-4-yl]-2-hydroxypropyl]-N-(cyclopentylmethyl)-4-methoxybenzenesulfonamide
CFAMM00324503 CHEMBL217771 Bioactive N-[(2S)-3-[(6S)-6-benzyl-8-oxo-4-oxa-7-azaspiro[2.5]octan-7-yl]-2-hydroxypropyl]-N-(cyclopentylmethyl)-4-methoxybenzenesulfonamide
CFAMM00324509 CHEMBL324144 Bioactive pyrrolidone 7
CFAMM00324506 CHEMBL117437 Bioactive spirocyclic morpholinone 6

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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