CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM15169
Family Name Vasopressin V2 receptor and Vasopressin V1a receptor ligand SureCN7389615 family
No. of Seeds 2 No. of Other Members 1
Family Centroid CFAMM00432666 Functional Category Bioactive
Superfamily Mast/stem cell growth factor receptor Kit and Vascular endothelial growth factor receptor 2 Ligand Motesanib Superfamily
Class Class 144

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Histidine decarboxylase Inhibitor Bf-derm1 Family 12 95
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Neuromedin-K receptor Ligand SB222200 Family 17 235
Cholecystokinin receptor type A Ligand Tarazepide Family 6 323
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
Glutamate receptor AMPA subtype Ligand CX-516 Family 9 24
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Histone deacetylase Inhibitor JNJ-26481585 Family 2 5
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
XL-888 family 16 85
Platelet activating factor, putative Inhibitor ABT-491 Family 22 62
Class II cytokine receptor Ligand IL-10 Family 7 45
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Cyclin-dependent kinase 4 Inhibitor 1-(9-oxo-9h-fluoren-4-yl)-... 3 5
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Transient receptor potential cation channel subfamily V member... 6 23
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 37 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-2... 8 1
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Hydroxycarboxylic acid receptor 2 Ligand 2-(6-phenylhexyl)pyri... 4 11
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Glutamate receptor 1 Ligand Piriqualone Family 8 67
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 27
Endothelin B receptor Ligand IRL-2500 Family 34 87
Amine oxidase [flavin-containing] A Inhibitor N-benzyl-1h-pyrr... 12 46
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Metabotropic glutamate receptor 5 Ligand 3-cyano-5-fluoro-n-(p... 2 9
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 3
Platelet-activating factor receptor ligand 8-bromo-2-[4-(2-met... 2 2
Sodium-dependent serotonin transporter and Sodium-dependent do... 10 2
Coagulation factor X inhibitor AGN-PC-075AY8 family 28 21
Histamine H3 receptor ligand AGN-PC-04YWRD family 5 13
Cell division cycle 7-related protein kinase inhibitor pyrrolo... 4 10
Gonadotropin-releasing hormone receptor ligand AGN-PC-075KV1 f... 4 1
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 36
Thyroid hormone receptor beta and Microtubule-associated prote... 1 8
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family 8 15
Tyrosine-protein kinase ITK/TSK and Receptor-type tyrosine-pro... 1 0
Mitogen-activated protein kinase 9 and MAP kinase-activated pr... 1 0
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
Dipeptidyl peptidase 4 and Potassium voltage-gated channel sub... 9 0
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Serine/threonine-protein kinase PLK1 and MAP kinase-activated ... 1 2
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... 6 4
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Aurora kinase A and Aurora kinase B inhibitor 4-fluoro-N-[4-[(... 6 1
Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... 2 0
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Coagulation factor X inhibitor 5-bromo-N-(5-chloropyridin-2-yl... 1 1
Coagulation factor X inhibitor AGN-PC-078Y0S family 7 1
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 5 0
Integrin beta-3 and Integrin alpha-V inhibitor 2-[(2S)-4-methy... 2 0
Platelet-activating factor receptor ligand (4R)-N-(3-benzoylph... 2 1
Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... 1 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
Epidermal growth factor receptor ligand (E)-5-[4-(3-bromoanili... 11 0
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 2 4
Tyrosine-protein kinase ITK/TSK and Insulin receptor ligand AG... 5 1
Macrophage colony-stimulating factor 1 receptor ligand SureCN1... 2 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00432666 CHEMBL299532 Bioactive SureCN7389615
CFAMM00432668 CHEMBL71355 Bioactive SureCN5739957

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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