CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1518
Family Name Calpain-1 catalytic subunit inhibitor 6-chloro-2-methyl-1,1-dioxo-N-[(2S)-1-oxo-3-phenylpropan-2-yl]-3,4-dihydro-1$l^{6},2-benzothiazine-3-carboxamide family
No. of Seeds 3 No. of Other Members 9
Family Centroid CFAMM00324524 Functional Category Bioactive
Superfamily Cruzipain and Beta-lactamase Binder Superfamily 3
Class Class 1321

Cousin Family NamesSeedsMembers
Cathepsin B and Cathepsin S Inhibitor Ac-hphe-leu-ala-leuvsme ... 17 51
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-(2-p... 6 19
Calpain Inhibitor SJA-6017 Family 2 12
Cathepsin L1 and Cathepsin B inhibitor (2S)-3-methyl-N-[(2S)-4... 7 24
Matrix metalloproteinase-9 and Stromelysin-1 inhibitor N-[(2S)... 1 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 7 1
Growth hormone secretagogue receptor type 1 ligand [(3S)-3-ami... 2 6
Growth hormone secretagogue receptor type 1 ligand [(3R)-3-ami... 2 5
Neutrophil elastase inhibitor 1-[(2S)-2-[(4-chlorophenyl)sulfo... 1 0
Aldose reductase inhibitor 4-chloro-2-(2,5-dioxoimidazolidin-4... 4 22


External ID

Functional Category

Molecule Name

CFAMM00324524 CHEMBL117553 Bioactive 6-chloro-2-methyl-1,1-dioxo-N-[(2S)-1-oxo-3-phenylpropan-2-yl]-3,4-dihydro-1$l^{6},2-benzothiazine-3-carboxamide
CFAMM00324521 CHEMBL118688 Bioactive 6,7-dichloro-2-methyl-1,1-dioxo-N-[(2S)-1-oxo-3-phenylpropan-2-yl]-3,4-dihydro-1$l^{6},2-benzothiazine-3-carboxamide
CFAMM00324527 CHEMBL8378 Bioactive 6-chloro-2-ethyl-1,1-dioxo-N-[(2S)-1-oxo-3-phenylpropan-2-yl]-3,4-dihydro-1$l^{6},2-benzothiazine-3-carboxamide

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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