CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1519
Family Name Muscarinic acetylcholine receptor M2 ligand AGN-PC-0745NK family
No. of Seeds 2 No. of Other Members 6
Family Centroid CFAMM00324539 Functional Category Bioactive
Superfamily Cannabinoid receptor 2 and Cannabinoid receptor 1 Binder Superfamily 8
Class Class 1827

Cousin Family NamesSeedsMembers
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapone Family 9 243
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Histamine H1 receptor Ligand Triprolidine Family 19 316
SUR2-type K(ATP) channel Ligand Nicorandil Family 5 85
Prothrombin Inhibitor Ximelegatran Family 8 157
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Coagulation factor X Inhibitor Otamixaban Family 9 21
Glutamate receptor AMPA subtype Ligand CX-516 Family 9 24
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Substance-P receptor Ligand TAK-637 Family 18 63
Amg 423 family 7 47
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Macrophage metalloelastase Inhibitor PF-00356231 Family 5 79
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Integrin beta-3 Inhibitor Elarofiban Family 28 45
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Integrin beta-3 Inhibitor L-739758 Family 2 4
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 93
Alpha-1A adrenergic receptor Ligand L-771688 Family 8 14
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Transient receptor potential cation channel subfamily V member... 6 23
Histone deacetylase 1 Inhibitor N-hydroxy-5-(pyridin-3-yl)thio... 9 46
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
C-C chemokine receptor type 5 Ligand GT-1282 Family 21 14
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
Rho-associated protein kinase 2 and cAMP-dependent protein kin... 2 7
Deoxycytidine kinase inhibitor N-[(1S,3S)-3-(4-amino-5-fluoro-... 2 5
Substance-K receptor ligand 6-methyl-N-[1-[[(2S)-1-phenyl-5-[4... 4 0
Sonic hedgehog protein inhibitor 3-chloro-N-[4-(methylamino)cy... 2 3
Neuronal acetylcholine receptor subunit alpha-7 and Acetylchol... 2 3
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor lig... 2 8
Histamine H3 receptor ligand AGN-PC-04YWRD family 5 13
Serine/threonine-protein kinase Chk1 inhibitor SureCN3070314 f... 16 32
Cellular tumor antigen p53 and Ferritin light chain inhibitor ... 1 2
Platelet-activating factor receptor ligand YM-461 family 1 11
Prostaglandin E2 receptor EP4 subtype ligand AGN-PC-09QJ7P family 2 0
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04SK7R family 3 3
Neuromedin-K receptor ligand 3-methylsulfinyl-N-[(1S)-1-phenyl... 3 5
Substance-K receptor ligand N-[1-[[(2R)-5-[4-(oxan-4-ylmethyl)... 2 0
Histamine H3 receptor ligand SureCN1857507 family 1 4
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 1 2
Glycogen synthase kinase-3 beta inhibitor 7-(6-chloropyridin-2... 2 3
Neuronal acetylcholine receptor subunit alpha-7 ligand AGN-PC-... 7 1
Neuronal acetylcholine receptor subunit alpha-7 and Neuronal a... 8 5
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 9 16
Delta-type opioid receptor and Potassium voltage-gated channel... 2 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 5 5
Cell division cycle 7-related protein kinase and Protein DBF4 ... 2 1
Orexin receptor type 1 and Orexin receptor type 2 ligand N-[[(... 9 5
Oxytocin receptor ligand (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)... 20 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 5 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 2 3
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 2 0
Probable G-protein coupled receptor 142 ligand (2S)-N-(2-oxo-5... 2 1
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 6 8
Motilin receptor ligand SureCN2768052 family 3 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 4 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 6-(b... 5 5
Platelet-activating factor receptor ligand (1-ethylindol-3-yl)... 17 13
Platelet-activating factor receptor ligand N,N-diethyl-3-[(4R)... 11 0
Platelet-activating factor receptor ligand (4R)-N-(3-benzoylph... 2 1
Platelet-activating factor receptor ligand SureCN9853140 family 3 3
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 1 1
Vesicular acetylcholine transporter and Sigma non-opioid intra... 2 0
1-(thiophen-2-yl)-8H-benzo[c]indolo[3,2,1-ij][1,5]naphthyridin... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00324535 CHEMBL196472 Bioactive 4-phenylsulfanyl-N-[(2R,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]benzamide
CFAMM00324539 CHEMBL11756 Bioactive AGN-PC-0745NK

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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