CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM15192
Family Name Dihydrofolate reductase and Dihydrofolate reductase type 1 inhibitor 5-[(8-methoxy-2,2,4-trimethyl-1H-quinolin-6-yl)methyl]pyrimidine-2,4-diamine family
No. of Seeds 8 No. of Other Members 1
Family Centroid CFAMM00432772 Functional Category Bioactive
Superfamily Peptide deformylase, mitochondrial Inhibitor Epiroprim Superfamily
Class Class 831

Cousin Family NamesSeedsMembers
Peptide deformylase, mitochondrial Inhibitor Trimethoprim Family 67 482
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Histamine H1 receptor Ligand Mepyramine Family 5 65
Serine/threonine-protein kinase Chk1 and Serine/threonine-prot... 23 121
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Hypoxia-inducible factor 1-alpha Inhibitor Hif-1alpha Family 7 107
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
Corticotropin-releasing factor receptor 1 Ligand GW876008 Family 3 30
AP26113 family 16 90
SB1518 family 7 103
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Tyrosine kinase Inhibitor PKI166 Family 17 198
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Reverse transcriptase Inhibitor UK-129485 Family 23 221
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 1 15
Vascular endothelial growth factor receptor 2 and Angiopoietin... 2 11
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 3
Adenosine kinase inhibitor 5-[3-(4-methoxyphenyl)propyl]-6-[2-... 2 11
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
D(2) dopamine receptor and Alpha-1B adrenergic receptor ligand... 2 8
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 3 20
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Dihydrofolate reductase inhibitor AC1L9XPA family 6 5
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Lethal factor and Dual specificity protein kinase CLK4 inhibit... 1 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
ALK tyrosine kinase receptor and Insulin receptor ligand SureC... 7 1
Prostaglandin D2 receptor ligand 2-[3-[2-methoxy-6-[2-(4-metho... 4 12
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Adenosine receptor A3 ligand AGN-PC-08WSLM family 5 22
Proto-oncogene tyrosine-protein kinase Src and Epidermal growt... 9 9
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 9 10
Insulin-like growth factor 1 receptor and Potassium voltage-ga... 2 2
Dihydrofolate reductase inhibitor 7-(3,4-dimethoxyphenyl)-6-me... 1 3
Dihydrofolate reductase inhibitor 7-(2-ethoxynaphthalen-1-yl)-... 3 2
cGMP-specific 3',5'-cyclic phosphodiesterase and Rod cGMP-spec... 42 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 2
ALK tyrosine kinase receptor ligand CHEMBL1946804 family 3 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Adenosine kinase inhibitor (2R,3R,4R)-2-[4-(2,3-dihydro-1,4-be... 5 2
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Eukaryotic translation initiation factor 2-alpha kinase 3 inhi... 1 1
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 0
Beta-secretase 1 and Beta-secretase 2 inhibitor 7-fluoro-3-(5-... 2 7
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 0
Cathepsin K and Cathepsin L1 inhibitor 2-Cyano-pyrimidine, 17a... 5 8
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 2 6
Dihydrofolate reductase inhibitor AGN-PC-001U7R family 3 0
Type-1 angiotensin II receptor ligand 2-ethyl-6-methoxy-N-[[4-... 2 0
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 1 0
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 1 3
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 15 1
Epidermal growth factor receptor ligand Pyrido[3,4-d]pyrimidin... 3 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 7 6
Protein kinase C theta type inhibitor SureCN3953579 family 2 1
Nuclear receptor ROR-gamma and Cytochrome P450 3A4 ligand NCGC... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00432775 CHEMBL60647 Bioactive 5-[(8-methoxy-2,2,4-trimethyl-3,4-dihydro-1H-quinolin-6-yl)methyl]pyrimidine-2,4-diamine
CFAMM00432774 CHEMBL300385 Bioactive 5-[(8-methoxy-1,2,2,4-tetramethylquinolin-6-yl)methyl]pyrimidine-2,4-diamine
CFAMM00432773 CHEMBL58038 Bioactive 5-[(8-methoxy-4-methyl-1,2,3,4-tetrahydroquinolin-6-yl)methyl]pyrimidine-2,4-diamine
CFAMM00432772 CHEMBL418492 Bioactive 5-[(8-methoxy-2,2,4-trimethyl-1H-quinolin-6-yl)methyl]pyrimidine-2,4-diamine
CFAMM00432771 CHEMBL418293 Bioactive 5-[[3-fluoro-2-(fluoromethyl)-8-methoxy-2,4-dimethyl-1H-quinolin-6-yl]methyl]pyrimidine-2,4-diamine
CFAMM00432776 CHEMBL58149 Bioactive 5-[[2,4-bis(fluoromethyl)-8-methoxy-2-methyl-1H-quinolin-6-yl]methyl]pyrimidine-2,4-diamine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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